Global Roll-out Cold Chain Training A Success Story F. Hoffmann-La Roche & Kuehne + Nagel

Kuehne + Nagel The Global Logistics Network + 100 countries + 900 locations + 61 500 employees + 7 million m² of warehouse space Kuehne + Nagel - QSHE Expert Team Pharma - QETP 25-Mar-17

The global logistics network is our strongest asset The global logistics network is our strongest asset. Dedication, integration and innovation are at the heart of our business philosophy. Focused on our customers’ needs we provide integrated logistics solutions of outstanding quality and operational excellence – we are the extension of your business. Mission Statement Kuehne + Nagel - QSHE Expert Team Pharma - QETP 25-Mar-17

Ensure a World Class Global Network designed Roche Pharma Technical Operations Objective Ensure a World Class Global Network designed to ensure a High Quality Supply to our patients. Kuehne + Nagel - QSHE Expert Team Pharma - QETP 25-Mar-17

High Quality Supply to the Patients Global Cold Chain Training Kuehne + Nagel has developed & initiated various projects with F. Hoffmann-La Roche, which support Roche‘s strategic logistics agenda whilst enhancing Kuehne + Nagel‘s competence in developing tailor-made solutions for the pharmaceutical industry, across all continents around the globe. One of these initiatives is the global roll-out of the Cold Chain Training - CCT: Kuehne + Nagel is the first external logistics supplier to execute the CCT on a global basis outside Roche. CCT offers a good opportunity and leverage to further strengthen and expand the successful cooperation between Roche and Kuehne + Nagel. Our target is to support Roche to ensure highest quality supply to the patient. Kuehne + Nagel - QSHE Expert Team Pharma - QETP 25-Mar-17

High Quality Supply to the Patients Global Cold Chain Training Scope F. Hoffmann-La Roche - global distribution network Services: Air Logistics Road Logistics Sea Logistics Contract Logistics Temperature ranges +2/+8°C and +15/+25°C Finished goods Kuehne + Nagel - QSHE Expert Team Pharma - QETP 25-Mar-17

Kuehne + Nagel serves F. Hoffmann-La Roche Global Distribution Network North America Europe CEMAI CEMAI Asia Pacific Latin America Kuehne + Nagel - QSHE Expert Team Pharma - QETP 25-Mar-17

Achievements High Quality Supply to the Patients Enhanced GXP knowledge in all regions Implementation of best practices Development of tailor-made processes Implementation of quality tools Sharing experiences and lessons learned Strategic cooperation with Kuehne + Nagel Initial international Cold Chain Training in Switzerland Improvement of the Supply Chain Security Ensuring highest quality supply to the patients Further development of the Roche Cold Chain Training Strategic cooperation with Kuehne + Nagel Initial international Cold Chain Training in Switzerland Improvement of the Supply Chain Security Ensuring highest quality supply to the patients Further development of the Roche Cold Chain Training Kuehne + Nagel - QSHE Expert Team Pharma - QETP 25-Mar-17

QSHE GXP Training from Kuehne + Nagel Global Quality Standards Kuehne + Nagel further developed the training material according to its organisation and processes. KN PHARMA LOGISTICS QSHE EXPERT TEAM PHARMA REGULATORY FRAMEWORK TRAININGS PHARMA MANUAL & SOPs COMPETENCE CENTER TOOLBOX INFORMATION POOL Kuehne + Nagel‘s GLOBAL PHARMA NETWORK Kuehne + Nagel - The Global Logistics Network Kuehne + Nagel - QSHE Expert Team Pharma - QETP QSHE – Quality, Safety & Health, Environment + Security 25-Mar-17

QUALITY EXPERT TEAM PHARMA Quality Expert Team Pharma Global Quality Standards QUALITY EXPERT TEAM PHARMA Global GXP Policy Manual GXP Training Concept Best Practices Implemen-tation Toolbox Global Roll-out The Global QSHE GXP Training has been integrated in the overall Global GXP Implementation Project. Kuehne + Nagel - QSHE Expert Team Pharma - QETP QSHE – Quality, Safety & Health, Environment + Security 25-Mar-17 p. 10 10 10 10

Cold Chain Training – Global QSHE GXP Training Roll-out Plan Overview Training by 9 Regions 555 Participants 60 Seminars Plan Regional CCT Prepare and adapt training material to local needs November 2011 1 Phase Conduct Regional CCT Phase 1 2 Phase Conduct Regional CCT Phase 2 Continuous Improvement Coordination of CCT activities and further development in close cooperation with all regions Kuehne + Nagel - QSHE Expert Team Pharma - QETP QSHE – Quality, Safety & Health, Environment + Security 25-Mar-17 p. 11

Cold Chain Training – Global QSHE GXP Training Global Roll-out GXP Trainings in more then 30 locations in 2011. In more then 60 locations until the end of 2012. Kuehne + Nagel - QSHE Expert Team Pharma - QETP QSHE – Quality, Safety & Health, Environment + Security 25-Mar-17