Ingeborg Friehs, MD, Christof Stamm, MD, Hung Cao-Danh, PhD, Francis X

Slides:

Advertisements

Similar presentations

Electron transport chain dysfunction in neonatal pressure-overload hypertrophy precedes cardiomyocyte apoptosis independent of oxidative stress Eric.

Advertisements

Celsior versus custodiol: early postischemic recovery after cardioplegia and ischemia at 5°C Juergen Ackemann, MD, Wolfgang Gross, PhD, Martin Mory,

Mary E. Huerter, MD, MA, Ashish K

Darren J. Bridgewater, Jackie Ho, Victor Sauro, Douglas G. Matsell

Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia- Reperfusion Injury in Diabetic Rats Juchen Li, MD, Yixing Ren, MD,

Volume 104, Issue 3, Pages (September 1993)

Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C Mamoru Munakata,

Bryan A. Whitson, MD, Blake A

Meena Nathan, MD, Ingeborg Friehs, MD, Yeong-Hoon Choi, MD, Douglas B

P38 Mitogen Activated Protein Kinase Mediates Both Death Signaling and Functional Depression in the Heart Meijing Wang, MD, Ben M. Tsai, MD, Mark W.

Terje K. Steigen, MD, Ellen Aasum, MS, Truls Myrmel, MD, PhDa, Terje S

Cytokines Link Toll-Like Receptor 4 Signaling to Cardiac Dysfunction After Global Myocardial Ischemia John Cha, MD, Zhiping Wang, MD, Lihua Ao, BS, Ning.

Preconditioning with cromakalim improves long-term myocardial preservation for heart transplantation Matthias Kirsch, MD, Christophe Baufreton, MD, PhD,

Nathalie Roy, MD, Ingeborg Friehs, MD, Douglas B

Effect of perfusion flow rate on tissue oxygenation in newborn piglets during cardiopulmonary bypass Gregory Schears, MD, Steven E Schultz, MD, Jennifer.

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: Phosphorus 31—nuclear magnetic resonance measurements.

Beneficial Effects of Fluosol–Polyethylene Glycol Cardioplegia on Cold, Preserved Rabbit Heart Joginder N Bhayana, MD, Zhong T Tan, MD, PhD, Jacob Bergsland,

Inhibition of protein kinase Cα improves myocardial β-adrenergic receptor signaling and ventricular function in a model of myocardial preservation Karen.

Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5 Edward P Chen, MD, Hartmuth B Bittner, MD, PhD,

Increased susceptibility of hypertrophied hearts to ischemic injury

Long-term myocardial preservation: effects of hyperkalemia, sodium channel, and NA+/K+/2CL- cotransport inhibition on extracellular potassium accumulation.

Vascular Endothelial Growth Factor Prevents Endothelial-to-Mesenchymal Transition in Hypertrophy Ben M.-W. Illigens, MD, Alejandra Casar Berazaluce,

Improved profile of bad phosphorylation and caspase 3 activation after blood versus crystalloid cardioplegia Jun Feng, MD, PhD, Cesario Bianchi, MD,

Proteasome Inhibition Attenuates Infarct Size and Preserves Cardiac Function in a Murine Model of Myocardial Ischemia-Reperfusion Injury William E. Stansfield,

Prolonged preservation of the blood-perfused canine heart with glycolysis-promoting solution Koh Takeuchi, MD, Hung Cao-Danh, PhD, Akihiko Kawai, MD,

Long-term treatment with nipradilol, a nitric oxide–releasing β-adrenergic blocker, enhances postischemic recovery and limits infarct size Yoshihiro.

Opioid preconditioning: myocardial function and energy metabolism

Promoting angiogenesis protects severely hypertrophied hearts from ischemic injury Ingeborg Friehs, MD, Adrian M Moran, MD, Christof Stamm, MD, Yeong-Hoon.

Terminal Warm Blood Cardioplegia Improves Cardiac Function Through Microtubule Repolymerization Hironori Tenpaku, MD, Koji Onoda, MD, Kyoko Imanaka-Yoshida,

Continuous warm versus intermittent cold cardioplegic infusion: A comparison of energy metabolism, sodium-potassium adenosine triphosphatase activity,

Effects of cardioplegia on vascular function and the “no-reflow" phenomenon after ischemia and reperfusion: Studies in the isolated blood-perfused rat.

Myocyte apoptosis occurs early during the development of pressure-overload hypertrophy in infant myocardium Yeong-Hoon Choi, MD, Douglas B. Cowan, PhD,

Aldo R. Castañeda, MD, PhD: Recipient of the Lifetime Achievement Award and 74th president of The American Association for Thoracic Surgery Pedro J.

Hermann Aebert, MD, Torsten Cornelius, BS, Tobias Ehr, BS, Stephan R

Bradykinin pretreatment improves ischemia tolerance of the rabbit heart by tyrosine kinase mediated pathways Jun Feng, MD, PhD, Eliot R Rosenkranz, MD

E. Marty Knott, Jie Sun, BS, Yu Lei, Myoung-Gwi Ryou, MS, Albert H

Exogenous magnesium chloride-adenosine triphosphate administration during reperfusion reduces the extent of necrosis in previously ischemic skeletal muscle

Periostin Is a Novel Factor in Cardiac Remodeling After Experimental and Clinical Unloading of the Failing Heart William E. Stansfield, MD, Nancy M.

Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment Juan A. Crestanello, MD.

Cardioplegia and vascular injury

Experimental study of intermittent crossclamping with fibrillation and myocardial protection: Reduced injury from shorter cumulative ischemia or intrinsic.

Cavopulmonary anastomosis induces pulmonary expression of the angiotensin II receptor family Sunil P. Malhotra, MD, V.Mohan Reddy, MD, Stephan Thelitz,

Aging reduces postischemic recovery of coronary endothelial function

Resuscitation of Non-Beating Donor Hearts Using Continuous Myocardial Perfusion: The Importance of Controlled Initial Reperfusion Satoru Osaki, MD, Kozo.

Gregory A Thomas, MD, Larry W Stephenson, MD

Patient recovery after intermittent disc escape and spontaneous recession of a mechanical heart valve Francis Robicsek, MD, PhD, Joseph W. Cook, MD

Inhibition of Glycogen Synthase Kinase-3β Improves Tolerance to Ischemia in Hypertrophied Hearts Rodrigo Barillas, MD, MBA, Ingeborg Friehs, MD, Hung.

Ulinastatin attenuates reperfusion injury in the isolated blood-perfused rabbit heart Zhi-Li Cao, MD, Yukio Okazaki, MD, Kozo Naito, MD, Tetsuya Ueno,

Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest Ru Lin,

Vascular Endothelial Growth Factor Attenuates Myocardial Ischemia-Reperfusion Injury Zhengyu Luo, Maurizio Diaco, Toyoaki Murohara, Napoleone Ferrara,

Reactive hyperemia during early reperfusion as a determinant of improved functional recovery in ischemic preconditioned rat hearts Annie Rochetaing,

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Heat shock improves recovery and provides protection against global ischemia after hypothermic storage Ashok Gowda, MS, Chunjie Yang, MD, Gregory K Asimakis,

Postischemic Function and Protein Kinase C Signal Transduction

Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide James D. McCully, PhD, Anthony J.

Interleukin-1β inhibits PDGF-BB−induced migration by cooperating with PDGF-BB to induce cyclooxygenase-2 expression in baboon aortic smooth muscle cells

2,3-Butanedione monoxime cardioplegia: advantages over hyperkalemia in blood- perfused isolated hearts A.Mark Jayawant, MD, Edward R. Stephenson, MD,

Neal S Goldstein, MD The Annals of Thoracic Surgery

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

David J Chambers, PhD, David J Hearse, DSc

Early effects of hypothyroidism on the contractile function of the rat heart and its tolerance to hypothermic ischemia Manuel Galiñanes, MD, PhD, Ryszard.

Insulin-induced improvement of postischemic recovery is abolished by inhibition of protein kinase C in rat heart Ulrich Fischer-Rasokat, BS, Torsten.

Mechanisms responsible for cell volume regulation during hyperkalemic cardioplegic arrest Xiwu Sun, MD, PhD, Christopher T Ducko, MD, Eric M Hoenicke,

The Annals of Thoracic Surgery

Adnan Cobanoglu, MD, Jess M Schultz, MD The Annals of Thoracic Surgery

Inhibition of the pacemaker current: a bradycardic therapy for off-pump coronary operations Alain Bel, MD, Louis P Perrault, MD, PhD, Bouchaib Faris,

Randy M. Stevens, MD, M. Salik Jahania, MD, Robert M

Insulin improves functional and metabolic recovery of reperfused working rat heart Torsten Doenst, MD, R.Todd Richwine, MS, Molly S Bray, PhD, Gary W.

Koh Takeuchi, MD, Pedro J. del Nido, MD, Andra E

Presentation transcript:

Insulin-like growth factor-1 improves postischemic recovery in hypertrophied hearts Ingeborg Friehs, MD, Christof Stamm, MD, Hung Cao-Danh, PhD, Francis X. McGowan, MD, Pedro J. del Nido, MD The Annals of Thoracic Surgery Volume 72, Issue 5, Pages 1650-1656 (November 2001) DOI: 10.1016/S0003-4975(01)03098-3

Fig 1 Glucose uptake measured as accumulation of 2-Deoxyglucose-6-phosphate (2-DG-6-P) by 31P-NMR spectroscopy over a period of 30 minutes in hypertrophied hearts (Hyper), age-matched nonhypertrophied control hearts (Control), insulin-like growth factor-1-perfused hypertrophied hearts (Hyper+IGF), and IGF-1+wortmannin-perfused hypertrophied hearts (Hyper+IGF/wort). n = 6/group, *p ≤ 0.05 versus Hyper+IGF and Control. All solutions contained a constant amount of insulin (10 IU/L). The Annals of Thoracic Surgery 2001 72, 1650-1656DOI: (10.1016/S0003-4975(01)03098-3)

Fig 2 Developed pressure measured 30 minutes after reperfusion (expressed as percent of preischemic values) in hypertrophied hearts (Hyper) with and without insulin-like growth factor-1 (Hyper + IGF-1) perfusion, with IGF-1+wortmannin (Hyper+IGF/wort) containing perfusate, and age-matched nonhypertrophied control hearts. n = 6/group, *p ≤ 0.05 versus IGF-1 perfused hypertrophied hearts and age-matched control hearts (Control). The Annals of Thoracic Surgery 2001 72, 1650-1656DOI: (10.1016/S0003-4975(01)03098-3)

Fig 3 (A) Representative blot of phosphatidylinositol-3-kinase (PI-3-kinase) activity in antiinsulin-receptor-substrate-1 immunoprecipitates from left ventricular muscle extracts of hypertrophied hearts perfused with Krebs-Henseleit (KH) solution containing insulin only or KH containing insulin+insulin-like growth factor-1 (IGF-1) compared with hearts from age-matched control animals perfused with KH containing insulin or insulin/wortmannin. The radioactivity at the origin is caused by [32P] ATP residues and other 32P-labeled materials. PIP indicates the position of migration of PI-3-P standard. (B) Summary of densitometry values expressed as arbitrary densitometry units for the three groups. *p ≤ 0.05; versus IGF-1-perfused hypertrophied hearts and age-matched control. The Annals of Thoracic Surgery 2001 72, 1650-1656DOI: (10.1016/S0003-4975(01)03098-3)

Fig 4 (A) Representative Western immunoblot of phosphatidylinositol-3-kinase (PI-3-kinase) protein of antiinsulin-receptor-substrate-1 immunoprecipitates from left ventricular muscle extracts from hypertrophied hearts perfused with Krebs-Henseleit (KH) solution containing insulin only or KH containing insulin and insulin-like growth factor-1 (IGF-1) compared with hearts from age-matched control animals perfused with KH containing insulin. (B) Summary of densitometry values expressed as arbitrary densitometry units for the three groups. There is no significant difference of PI-3-kinase protein content in any group. The Annals of Thoracic Surgery 2001 72, 1650-1656DOI: (10.1016/S0003-4975(01)03098-3)