Presentation is loading. Please wait.

Presentation is loading. Please wait.

Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest  Ru Lin,

Similar presentations


Presentation on theme: "Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest  Ru Lin,"— Presentation transcript:

1 Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest  Ru Lin, MD, PhD, Ze-Wei Zhang, MD, Qi-Xing Xiong, MD, Chun-Mei Cao, PhD, Qiang Shu, MD, Iain C. Bruce, PhD, Qiang Xia, PhD  The Annals of Thoracic Surgery  Volume 78, Issue 3, Pages (September 2004) DOI: /j.athoracsur

2 Fig 1 Recovery of intracellular calcium ([Ca2+]i) transient in isolated rat cardiomyocytes during perfusion with Krebs-Henseleit solution (95% O2/5% CO2 at 24°C) after cardioplegic arrest for 2 hours. Data are expressed as mean ± standard deviation. *p < 0.05; **p < 0.01 versus control (n = 8); ##p < 0.01 versus cardioplegic solution only (CP; n = 8); ΔΔp < 0.01 versus cardioplegic solution + pinacidil (CP+P; n = 12). (CP+P+G = cardioplegic solution + pinacidil + glibenclamide [n = 12].) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

3 Fig 2 Representative traces of calcium transients elicited by field stimulation and rapid application of caffeine. (CP = cardioplegic solution only; CP+P = cardioplegic solution + pinacidil; CP+P+G = cardioplegic solution + pinacidil + glibenclamide.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

4 Fig 3 Box plot of the amplitude of the intracellular calcium ([Ca2+]i) transient evoked by the rapid application of caffeine (10 mmol/L). **p < 0.01 versus control (n = 8); ##p < 0.01 versus cardioplegic solution only (CP; n = 8); Δp < 0.05 versus cardioplegic solution + pinacidil (CP+P; n = 9). (CP = cardioplegic solution only; CP+P = cardioplegic solution + pinacidil; CP+P+G = cardioplegic solution + pinacidil + glibenclamide [n = 8].) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

5 Fig 4 Box plot of the ratio between the intracellular calcium ([Ca2+]i) transient's decay time in response to caffeine and that induced by electrical stimulation. *p < 0.05; **p < 0.01 versus control (n = 9); #p < 0.05; ##p < 0.01 versus cardioplegic solution only (CP; n = 8); ΔΔp < 0.01 versus cardioplegic solution + pinacidil (CP+P; n = 8). (CP = cardioplegic solution only; CP+P = cardioplegic solution + pinacidil; CP+P+G = cardioplegic solution + pinacidil + glibenclamide [n = 8].) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )


Download ppt "Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest  Ru Lin,"

Similar presentations


Ads by Google