The AML Salad Bowl Cancer Cell

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The AML Salad Bowl Cancer Cell Jesús Duque-Afonso, Michael L. Cleary Cancer Cell Volume 25, Issue 3, Pages 265-267 (March 2014) DOI: 10.1016/j.ccr.2014.03.002 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Functional and Genetic Heterogeneity of Primary AML A founding AML clone arises with accumulation of a set of acquired “signature” mutations. During tumor progression, the founding clone evolves into genetically distinct subclones through the acquisition of new mutations. The complete spectrum of mutations defines morphological and phenotypic properties of the subclones that correlate with distinct functional characteristics, such as in vitro growth, engraftment in immune-deficient mice, or relapse in patients. Cancer Cell 2014 25, 265-267DOI: (10.1016/j.ccr.2014.03.002) Copyright © 2014 Elsevier Inc. Terms and Conditions