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New Views into the Genetic Landscape of Metastatic Breast Cancer

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1 New Views into the Genetic Landscape of Metastatic Breast Cancer
Xiaoyu Zhao, Scott Powers  Cancer Cell  Volume 32, Issue 2, Pages (August 2017) DOI: /j.ccell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Evolutionary Process of Metastatic and Locoregional Relapsed Breast Cancer Metastases diverge at a late point in the primary tumor development. Synchronous lymph-node metastases are more closely related to the primary tumor, compared to metachronous metastases. Additional driver mutations appeared to be acquired after dissemination. Recurrent additional driver genes include cancer genes rarely mutated in primary breast cancers. Cancer Cell  , DOI: ( /j.ccell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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