Enrichment of two rare SNPs among ABC DLBCL tumors.

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Enrichment of two rare SNPs among ABC DLBCL tumors. Enrichment of two rare SNPs among ABC DLBCL tumors. A, amino acid sequence (based on accession NP_060469) of a region of the UBA domain of RNF31 showing the residues altered by two SNPs, Q584H and Q622L, and the number and type of lymphoma biopsies in which they were identified. B, location of the residues altered by the RNF31 SNPs in two views of the three-dimensional structure of the RNF31 UBA domain. C, frequencies of RNF31 SNPs in biopsy samples from different lymphoma subtypes. Yibin Yang et al. Cancer Discovery 2014;4:480-493 ©2014 by American Association for Cancer Research