BCL-2 and BCL-XL expression alters with maturation stage of the T cell

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BCL-2 and BCL-XL expression alters with maturation stage of the T cell. BCL-2 and BCL-XL expression alters with maturation stage of the T cell. BCL-2 and BCL-XL protein expression was measured by FACS analysis, and the gating strategy for distinguishing the different stages of T-cell differentiation is shown in Supplementary Fig. S3. A, the expression of BCL-2 and BCL-XL is normalized to the double-positive stage and expressed in mean fluorescent units (MFU); the experiment was repeated three times and the mean ± SD is graphed. B, the mRNA expression of BCL-2 is shown for primary human cells at the listed stages of differentiation. These data are modified from the online database (37). C, the mRNA expression of BCL-2 and BCL-XL in both ETP-ALL and typical T-ALL is graphically depicted in a heat map, with red indicating high expression and blue indicating low expression. The data are modified from the published online database (38). D, the BCL-2/BCL-XL and MCL-1 protein levels are shown for the typical human T-ALL cell lines and samples (TALL-x-4, -9, -1, and -2) as well as the ETP-ALL cell line LOUCY and the relapsed ETP-ALL sample (TALL-x-11). E, ratio of BCL-2:BCL-XL protein is shown for the cell lines and primary samples examined in D. Triona Ni Chonghaile et al. Cancer Discovery 2014;4:1074-1087 ©2014 by American Association for Cancer Research