Effect of CDV on human SF7796 xenografts in vivo.

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Effect of CDV on human SF7796 xenografts in vivo. Effect of CDV on human SF7796 xenografts in vivo. A, ex vivo immunohistochemical staining for Ki-67, TUNEL, and cleaved caspase-3 in xenografts treated with CDV. Results shown for Ki-67 are at 2 weeks, although similar results were obtained at other time points. Representative photomicrographs (control and week 2) of TUNEL and cleaved caspase-3 immunohistochemical staining similarly show increased numbers of positive cells in the tumors of mice treated with CDV (magnification ×20). The third column of photographs shows lower magnification (×10) of the margin between invasive tumor and surrounding nontumor tissues. Positive cells (red arrows) were detected only in tumor areas of CDV-treated mice. Size bars = 200 μm. B, statistical analysis of staining for Ki-67, TUNEL, and cleaved caspase-3 between treated (black columns) and control animals (white columns) is shown as means ± SD. *, P < 0.001. C, Western blot analysis of extracts from SF7796 xenografts treated with CDV. CDV treatment results in increased phosphorylation of the histone H2A.X at Ser139. Piotr Hadaczek et al. Clin Cancer Res 2013;19:6473-6483 ©2013 by American Association for Cancer Research