FBXL19-AS1 knockdown inhibits proliferation, migration and invasion, and reduces the expression levels of angiogenesis related proteins in lung cancer.

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Presentation transcript:

FBXL19-AS1 knockdown inhibits proliferation, migration and invasion, and reduces the expression levels of angiogenesis related proteins in lung cancer cells (A) The knockdown efficiency of FBXL19-AS1 in A549 and H1299 cells was examined by RT-qPCR. FBXL19-AS1 knockdown inhibits proliferation, migration and invasion, and reduces the expression levels of angiogenesis related proteins in lung cancer cells (A) The knockdown efficiency of FBXL19-AS1 in A549 and H1299 cells was examined by RT-qPCR. (B) At the indicated time points (24, 48, 72 and 96 h), the proliferation of transfected cells was determined by CCK8 assay. (C) After 2 weeks of transfection, colony formation assay was performed. (D and E) Transwell assay presented that the knockdown of FBXL19-AS1 inhibits migration and invasion in A549 and H1299 cells. (F) After 48 h of transfection, protein expressions of VEGF, Ang1, and FGF2 were measured by Western blot assay. Error bars represent the mean ± SD of at least three independent experiments. **P<0.01 versus control group. Qian Jiang et al. Biosci. Rep. 2019;39:BSR20181804 ©2019 by Portland Press Ltd