DAC treatment activates expression of immunoregulatory genes.

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Skin Pharmacol Physiol 2017;30: DOI: /

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DAC treatment activates expression of immunoregulatory genes. DAC treatment activates expression of immunoregulatory genes. BR5FVB1-Akt ovarian cancer cells were treated with DAC for 72 hours, and total RNA was collected for mouse gene ST 2.0 microarray analysis. A, heatmap of DMSO control and DAC using unpaired one-way ANOVA (P < 0.05). Two independent biologic duplicates were evaluated, and the filter criterion was a linear fold change greater than 2. B, Gene Ontology (GO)-Map analysis reveals that immunoregulatory genes constitute the greatest percentage of upregulated genes by category. C, KEGG pathway analysis reveals that many of the upregulated gene sets are components of cytokine, chemokine, and innate immune signaling pathways. D, RT-PCR analysis confirms that treatment of BR5FVB1-Akt cells with DAC for 72 hours leads to upregulation of several immunoregulatory genes that can affect antitumor immunity. Lei Wang et al. Cancer Immunol Res 2015;3:1030-1041 ©2015 by American Association for Cancer Research