Early effects of hypothyroidism on the contractile function of the rat heart and its tolerance to hypothermic ischemia Manuel Galiñanes, MD, PhD, Ryszard.

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Presentation transcript:

Early effects of hypothyroidism on the contractile function of the rat heart and its tolerance to hypothermic ischemia Manuel Galiñanes, MD, PhD, Ryszard T. Smolenski, MD, Peter S. Haddock, PhD, David J. Hearse, PhD, DSc The Journal of Thoracic and Cardiovascular Surgery Volume 107, Issue 3, Pages 829-837 (March 1994) DOI: 10.5555/uri:pii:S0022522394703396 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 Effect of thyroidectomy on (A) LVDP, (B) LVdP/dtmax, (C) heart rate (HR), and (D) LVEDP 5 days after operation. Each column represents mean of eight measurements and bars represent standard error of mean. Asterisk indicates p < 0.05 when compared with sham-operated group. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 829-837DOI: (10.5555/uri:pii:S0022522394703396) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Effect of thyroidectomy (solid circles) on (A) systolic and (B) diastolic cardiac function when assessed 5 days after operation in isolated blood-perfused heart. Each point represents mean of eight measurements and bars represent standard error of mean. LV, Left ventricular. Asterisk indicates p < 0.05 when compared with sham-operated group (open circles). The Journal of Thoracic and Cardiovascular Surgery 1994 107, 829-837DOI: (10.5555/uri:pii:S0022522394703396) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Effect of thyroidectomy (solid circles) on (A) systolic and (B) diastolic cardiac function when assessed 5 days after operation in isolated blood-perfused heart. Each point represents mean of eight measurements and bars represent standard error of mean. LV, Left ventricular. Asterisk indicates p < 0.05 when compared with sham-operated group (open circles). The Journal of Thoracic and Cardiovascular Surgery 1994 107, 829-837DOI: (10.5555/uri:pii:S0022522394703396) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 Effect of thyroidectomy (hatched columns) on myocardial Na+-K+-ATPase activity when assessed 5 days after operation (total tissue ATPase activity can be derived by addition of ouabain-insensitive and ouabain-sensitive ATPase activity). Each column represents mean of seven hearts and bars represent standard error of mean. MIE, Mean integrated extinction. Asterisk indicates p < 0.05 when compared with corresponding sham-operated group (open columns). The Journal of Thoracic and Cardiovascular Surgery 1994 107, 829-837DOI: (10.5555/uri:pii:S0022522394703396) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 Effect of thyroidectomy (solid circles) on postischemic recovery of (A) systolic and (B) diastolic cardiac function after 6 hours of hypothermic (4° C) ischemia and 40 minutes of reperfusion (37° C) in isolated blood-perfused heart. Each point represents mean of eight measurements and bars represent standard error of mean. LV, Left ventricular. Asterisk indicates p < 0.05 when compared with sham-operated group (open circles). The Journal of Thoracic and Cardiovascular Surgery 1994 107, 829-837DOI: (10.5555/uri:pii:S0022522394703396) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 Effect of thyroidectomy (solid circles) on postischemic recovery of (A) systolic and (B) diastolic cardiac function after 6 hours of hypothermic (4° C) ischemia and 40 minutes of reperfusion (37° C) in isolated blood-perfused heart. Each point represents mean of eight measurements and bars represent standard error of mean. LV, Left ventricular. Asterisk indicates p < 0.05 when compared with sham-operated group (open circles). The Journal of Thoracic and Cardiovascular Surgery 1994 107, 829-837DOI: (10.5555/uri:pii:S0022522394703396) Copyright © 1994 Mosby, Inc. Terms and Conditions