Presentation is loading. Please wait.

Presentation is loading. Please wait.

Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction  Katsuhiko Nakanishi, MD,

Published byDewi Verawati Johan Modified over 5 years ago

Similar presentations

Presentation on theme: "Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction  Katsuhiko Nakanishi, MD,"— Presentation transcript:

1 Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction  Katsuhiko Nakanishi, MD, Zhi-Qing Zhao, PhD, J. Vinten-Johansen, PhD, Dudley A. Hudspeth, MD, D.Scott McGee, BS, John W. Hammon, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 109, Issue 6, Pages (June 1995) DOI: /S (95) Copyright © 1995 Mosby, Inc. Terms and Conditions

2 Fig. 1 Experimental protocol. Hearts placed on cardiopulmonary bypass were subjected to 30 minutes of normothermic global ischemia followed by 60 minutes of hypothermic cardioplegic arrest with multidose BCP (every 20 minutes). Thirty minutes were allowed for reperfusion in beating empty state, after which bypass was discontinued to convert heart to working state for another 30 minutes. Hemodynamic and left ventricular (LV) function data were obtained during baseline and after 60 minutes of reperfusion. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

3 Fig. 2 Variables describing analysis of systolic function by ESPVR in preischemic (Pre) and postishemic (Post) period. Top panel, Slope of ESPVR (Ees ). Middle panel, Volume axis intercept of ESPVR (Vo). Bottom panel, Volume axis value (VMID) at Pes within physiologic range (80 to 100 mm Hg), describing position of ESPVR. Asterisk, p < 0.05 versus preischemic period; plus sign, p < 0.05 versus VEH. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

4 Fig. 3 MPO activity, an index of neutrophil accumulation in postischemic myocardial tissue samples from each group. Asterisk, p < 0.05 versus VEH. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

5 Fig. 4 Concentration response curves to acetylcholine, the calcium ionophore A23187, and acidified sodium nitrite in coronary arterial rings from each group. Values are expressed as percent change in tension from precontraction with thromboxane A2 analogue U Asterisk, p < 0.05 versus VEH and SPM-L; plus sign, p < 0.05 versus VEH. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

Download ppt "Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction  Katsuhiko Nakanishi, MD,"

Similar presentations

Influence of normothermic systemic perfusion during coronary artery bypass operations: A randomized prospective study  Inderpaul Birdi, FRCS, Idris Regragui,

Influence of normothermic systemic perfusion during coronary artery bypass operations: A randomized prospective study  Inderpaul Birdi, FRCS, Idris Regragui,
L-Arginine, a nitric oxide precursor, attenuates ischemia-reperfusion injury by inhibiting inositol-1,4,5-triphosphate  Tomohiro Mizuno, MD, Masazumi.

L-Arginine, a nitric oxide precursor, attenuates ischemia-reperfusion injury by inhibiting inositol-1,4,5-triphosphate  Tomohiro Mizuno, MD, Masazumi.
Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat  Ryuzo Bessho, MD, PhD, David J. Chambers,

Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat  Ryuzo Bessho, MD, PhD, David J. Chambers,
Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization  Robert D. Riley, MD, Hiroki Sato, MD, PhD,

Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization  Robert D. Riley, MD, Hiroki Sato, MD, PhD,
Revascularization of severe hibernating myocardium in the beating heart: early hemodynamic and metabolic features  Evasio Pasini, MD, Gianna Ferrari,

Revascularization of severe hibernating myocardium in the beating heart: early hemodynamic and metabolic features  Evasio Pasini, MD, Gianna Ferrari,
Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial.

Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial.
Linear end-systolic pressure-volume relationship during pulsatile left ventricular bypass represents native heart function  Osamu Kawaguchi, MD, John.

Linear end-systolic pressure-volume relationship during pulsatile left ventricular bypass represents native heart function  Osamu Kawaguchi, MD, John.
Delivery of a nonpotassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: A new approach  Michael T. Kronon,

Delivery of a nonpotassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: A new approach  Michael T. Kronon,
Esmolol and percutaneous cardiopulmonary bypass enhance myocardial salvage during ischemia in a dog model  Glenn W. Laub, MD, S. Muralidharan, MD, Jerome.

Esmolol and percutaneous cardiopulmonary bypass enhance myocardial salvage during ischemia in a dog model  Glenn W. Laub, MD, S. Muralidharan, MD, Jerome.
Optimal flow rates for integrated cardioplegia

Optimal flow rates for integrated cardioplegia
Cardiac performance after deep hypothermic circulatory arrest in chronically cyanotic neonatal lambs  Mitsugi Nagashima, MDa, Georg Nollert, MDa, Ulrich.

Cardiac performance after deep hypothermic circulatory arrest in chronically cyanotic neonatal lambs  Mitsugi Nagashima, MDa, Georg Nollert, MDa, Ulrich.
The effect of ventricular volume reduction surgery in the dilated, poorly contractile left ventricle: A simple finite element analysis  Mark B. Ratcliffe,

The effect of ventricular volume reduction surgery in the dilated, poorly contractile left ventricle: A simple finite element analysis  Mark B. Ratcliffe,
Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J
Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation  Paul W.M. Fedak, MD, PhD, Vivek Rao,

Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation  Paul W.M. Fedak, MD, PhD, Vivek Rao,
Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: Phosphorus 31—nuclear magnetic resonance measurements.

Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: Phosphorus 31—nuclear magnetic resonance measurements.
Comparative Effects of Continuous Warm Blood and Intermittent Cold Blood Cardioplegia on Coronary Reactivity  Motohisa Tofukuji, MD, PhD, Alon Stamler,

Comparative Effects of Continuous Warm Blood and Intermittent Cold Blood Cardioplegia on Coronary Reactivity  Motohisa Tofukuji, MD, PhD, Alon Stamler,
Inhibition of protein kinase Cα improves myocardial β-adrenergic receptor signaling and ventricular function in a model of myocardial preservation  Karen.

Inhibition of protein kinase Cα improves myocardial β-adrenergic receptor signaling and ventricular function in a model of myocardial preservation  Karen.
Effects of amrinone, a phosphodiesterase inhibitor, on right ventricular/arterial coupling immediately after cardiac operations  Yoshie Ochiai, MD, Shigeki.

Effects of amrinone, a phosphodiesterase inhibitor, on right ventricular/arterial coupling immediately after cardiac operations  Yoshie Ochiai, MD, Shigeki.
Basal nitric oxide expresses endogenous cardioprotection during reperfusion by inhibition of neutrophil-mediated damage after surgical revascularization 

Basal nitric oxide expresses endogenous cardioprotection during reperfusion by inhibition of neutrophil-mediated damage after surgical revascularization 
Steven R. Gundry, MD, Matthew A. Romano, MD, O

Steven R. Gundry, MD, Matthew A. Romano, MD, O

Similar presentations

Ads by Google