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The effects of normothermic and hypothermic cardiopulmonary bypass on defibrillation energy requirements and transmyocardial impedance  David Martin,

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Presentation on theme: "The effects of normothermic and hypothermic cardiopulmonary bypass on defibrillation energy requirements and transmyocardial impedance  David Martin,"— Presentation transcript:

1 The effects of normothermic and hypothermic cardiopulmonary bypass on defibrillation energy requirements and transmyocardial impedance  David Martin, MBBS, MRCPa, Jose Garcia, MDb c, C.Robert Valeri, MDd, Shukri F. Khuri, MDb c, Mheir Doursounian, BS  The Journal of Thoracic and Cardiovascular Surgery  Volume 109, Issue 5, Pages (May 1995) DOI: /S (95) Copyright © 1995 Mosby, Inc. Terms and Conditions

2 Fig. 1 Sample family of dose-response curves derived from single hypothermic (group 1) experiment. Circles denote measurements made immediately after establishment of CPB; triangles and squares denote repeated dose-response measurements made after 1 and 2 hours of CPB, respectively. Note that abscissa scale is logarithmic. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

3 Fig. 2 Graph showing defibrillation energy requirements (E50 ) immediately after CPB is established (T0 ), after 1 hour (T1 ), and after 2 hours (T2 ). Hatched bars denote hypothermic (group 1) experiments; open bars denote normothermic (group 2) experiments. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

4 Fig. 3 Graph of pooled impedance data expressed as percentage of impedance at beginning of T0 defibrillation dose-response curve generation plotted for beginning and end of each series of inductions of ventricular fibrillation. Closed circles denote hypothermic (group 1) experiments; open circles denote normothermic (group 2) experiments. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

5 Fig. 4 Graph showing changes in extracellular intramyocardial pH during 2 hours of CPB. Symbols are as in Fig. 2. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

6 Fig. 5 Graph showing changes in heart rate during 2 hours of CPB. Symbols are as in Fig. 2. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

7 Fig. 6 Graph showing changes in LVEDP during 2 hours of CPB. Symbols are as in Fig. 2. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

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