Loss of ATF3 function modestly reduces axonal regeneration following sciatic nerve crush. Loss of ATF3 function modestly reduces axonal regeneration following.

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From: Nerve Injury-related Autoimmunity Activation Leads to Chronic Inflammation and Chronic Neuropathic Pain Anesthes. 2013;118(2): doi: /ALN.0b013e31827d4b82.

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Loss of ATF3 function modestly reduces axonal regeneration following sciatic nerve crush. Loss of ATF3 function modestly reduces axonal regeneration following sciatic nerve crush. A, B, There was no difference in axonal regeneration 2 d following injury between ATF3+/+, ATF3+/cre, and ATF3cre/cre mice (n = 7, n = 6, and n = 6, respectively, groups were compared with a one-way ANOVA on cumulative densities). C, D, ATF3cre/cre mice exhibited significantly diminished axonal regeneration 3 d following injury 2–4 mm distal to the injury compared to ATF3+/+ mice (n = 5 for both groups, one-way ANOVA followed by Dunnett’s multiple comparison test). The hemizygous group (n = 4) tested positive as a significant intermediary between both control and ATF3 null groups (post hoc test for trend). Dotted line indicates distal border of crush site, 500 μm from the edge of the block. Scale bars: 500 μm. Seth D. Holland et al. eNeuro 2019;6:ENEURO.0025-19.2019 ©2019 by Society for Neuroscience