1. The complexity as well as the total dendritic length of ApoE-deficient adult-born granule cells are significantly reduced.
The complexity as well as the total dendritic length of ApoE-deficient adult-born granule cells are significantly reduced. A, B, Representative 3D-reconstructed adult-born granule cells (4 weeks after stereotactic injections), one circle every 10 µm. C, Distance between the soma and the first dendritic division (in µm). D, Nodes were defined as the number of divisions of dendritic branches. E, Cumulative length of dendritic arborization (in µm). F, Span of the dendritic arborization when projected on two dimensions. G, Sholl analysis: the number of dendritic intersections as a function of the distance from the soma: wild type, 78 neurons/4 mice; ApoE-deficient, 73 neurons/7 mice. Results are expressed as the mean ± SEM. Independent t test and two-way-ANOVA with uncorrected Fisher’s LSD post hoc tests were used: *p < 0.05, **p < 0.01, ***p < Scale bar, B, 50 µm.
Yacine Tensaouti et al. eNeuro 2018;5:ENEURO
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