CO inhibits H2S generation through sGC-dependent cGMP production.

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Presentation transcript:

CO inhibits H2S generation through sGC-dependent cGMP production. CO inhibits H2S generation through sGC-dependent cGMP production. (A to D) Effects of siRNA silencing of sGCα1 on the generation of cGMP and H2S in response to either the CO donor CORM-2 (A and B) or coexpression of HO-2 (C and D) in HEK-293 cells expressing CSE. Scr, scrambled RNA. (E and F) Analysis of serine phosphorylation of CSE. Top: representative immunoblot; bottom: densitometric analysis. Effects of siRNA silencing of either sGCα1 or cGMP-dependent PKG II on serine phosphorylation in cells expressing CSE in response to CORM-2 (E) or in CSE/HO-2–coexpressing cells under normoxia or hypoxia or hypoxic cells returned to normoxia. (F) The graphs in (A) to (F) represent means ± SEM (n = 4 to 5 independent experiments). **P < 0.01. See fig. S3 for data on silencing sGC and PKG II by siRNA. I.P., immunoprecipitation. Guoxiang Yuan et al., Sci. Signal. 2015;8:ra37 Copyright © 2015, American Association for the Advancement of Science