SW fraction induces S phase arrest and apoptosis.

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SW fraction induces S phase arrest and apoptosis. SW fraction induces S phase arrest and apoptosis. A, BrdUrd–PI labeling of synchronized AGS and HT-29 cells treated with SW or solvent for 24 hours. BrdUrd-positive cells were determined as S phase fraction and shown as the percentage. Results from one representative experiment were shown. B, composite results of two BrdUrd–PI labeling experiments with duplicate samples. Columns, mean; bars, SD. C, annexin V–PI staining of AGS and HT-29 cells treated with SW. Percentages of apoptotic cells were shown by composite results of two experiments with duplicate samples. Columns, mean; bars, SD. D, TUNEL staining of paraffin-embedded MDA-MB-231 xenograft sections; scale bar, 100 μm. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Tiantian She et al. Cancer Prev Res 2015;8:464-474 ©2015 by American Association for Cancer Research