Biomarkers detected in the serum of rat recipients of intraomental biologic scaffold and intrahepatic syngeneic islets. Biomarkers detected in the serum.

Slides:

Advertisements

Similar presentations

Phase I Trial of Sorafenib in High-Risk Hepatocellular Carcinoma (HCC) Patients After Liver Transplantation (LT) AB Siegel, R Hidalgo, D Tsushima, J Zaretsky,

Advertisements

Therapies For T1D Insulin therapy Transplantation Islet Encapsulation.

Influence of conjugated linoleic acid (CLA) supplementation on Haptoglobin and Leptin during the lactation period in dairy cattle Amani Al-Dawood Supervised.

بهداشت فردي.

IL-6 Blockade Attenuates the Development of Murine Sclerodermatous Chronic Graft- Versus-Host Disease Doanh Le Huu, Takashi Matsushita, Guihua Jin, Yasuhito.

by Anil Dangi, Lei Zhang, Xiaomin Zhang, and Xunrong Luo

Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease by Tangsheng Yi, Dongchang Zhao, Chia-Lei.

Hydrodynamic Delivery of Human IL-15 cDNA Increases Murine Natural Killer Cell Recovery after Syngeneic Bone Marrow Transplantation Isabel Barao, Maite.

Type 1 immunity drives metabolic disease but protects against NAFLD

Volume 23, Issue 3, Pages (March 2016)

Volume 119, Issue 1, Pages (July 2000)

MRNA expression levels of the gene encoding CAR in isolated human islets from control donors, cultured for prolonged time (n=2). mRNA expression levels.

Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet.

Decreased P-IR and total FOXO1 levels in an HFS diet.

Cyp8b1−/− mice have an altered circulating bile acid pool.

A–L: Xenin-25 amplifies the effects of GIP on plasma insulin, C-peptide, and glucose levels and ISRs in humans with NGT and IGT but not T2DM. A–L: Xenin-25.

Analysis of peripheral blood CD4+CD25+ T-cells after B6

Glucose, insulin, and AGE levels during an OGC before and after RT

Changes (mean +SEM) in glucose, insulin, glucagon-like peptide (GLP)-1 and ghrelin from the baseline values after administration of placebo (broken lines.

1018-NT-β-cell clusters protect mice from STZ-induced diabetes.

Chronic brain insulin infusion reduces liver TG content independent of changes in body weight and food intake. Chronic brain insulin infusion reduces liver.

GSIS. GSIS. In vivo: serum insulin levels at fasting state and 30 min after glucose injection (A) and the fold change in serum insulin after glucose loading.

The procedure of alloislet transplantation in T1D recipients.

Expression of VCAM-1 and inflammatory cytokines in injured carotid arteries in STZ-induced diabetic rats. Expression of VCAM-1 and inflammatory cytokines.

N-3 resolution mediators improve insulin signaling by blunting JNK and iNOS in muscle and liver. n-3 resolution mediators improve insulin signaling by.

Left columns: Plasma glucose and serum insulin concentrations, circulating TF-PCA, and FVIIa activity before and during 24 h of selective hyperglycemia.

Immune cell activation detected by gene expression in representative pancreatic islets of IDDM rats after successful combination therapy with anti–TNF-α.

Comparison of the regression lines for AIRarg (the acute insulin response to intravenous arginine over 2–5 min after injection) and AIRargMAX (the response.

Mean ± SEM concentration of insulin in plasma and CSF and glucose in plasma 30 min after the intraperitoneal administration of DET or NPH insulin at different.

Figure 3 Fingolimod inhibits TNF-α secretion by human monocytes Peripheral blood mononuclear cells from healthy donors were briefly exposed to increasing.

Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells.

Measurement of insulin release from islets evoked by glucose, diazoxide, and high K+. Measurement of insulin release from islets evoked by glucose, diazoxide,

Effect of high-fat (breeder food) diet and 16 h of fasting on triglyceride levels and leptin transport. Effect of high-fat (breeder food) diet and 16 h.

A: QTL analysis of genotyping data on chromosome 12 revealed a locus linked to glucose levels in F2 mice at 6 months of age at marker D12Mit231 with a.

Effects of in vivo AICAR treatment on blood glucose and lactate concentrations. Effects of in vivo AICAR treatment on blood glucose and lactate concentrations.

Comparable function of intrahepatic and intraomental islets transplanted into biologic scaffolds. Comparable function of intrahepatic and intraomental.

Starvation-induced inhibition of leptin transport across the BBB is caused by a circulating factor. Starvation-induced inhibition of leptin transport across.

Intraperitoneal (IP) and intravenous (IV) milk fat inhibits leptin transport. Intraperitoneal (IP) and intravenous (IV) milk fat inhibits leptin transport.

Insulin sensitivity in athletes and sedentary normal-weight and obese, young, and old individuals. Insulin sensitivity in athletes and sedentary normal-weight.

Chop deletion preserves β-cell function in P58IPK−/− mice.

COX-2 deletion in macrophages led to increased renal macrophage infiltration in diabetic mice. COX-2 deletion in macrophages led to increased renal macrophage.

USP2–45 regulates hepatic gluconeogenesis.

Intracerebroventricular (ICV) insulin infusion increases TG secretion.

Sympathetic denervation decreases VLDL-TG secretion in the fasted state. Sympathetic denervation decreases VLDL-TG secretion in the fasted state. A: Plasma.

Effect of anandamide on blood glucose clearance and insulin sensitivity. Effect of anandamide on blood glucose clearance and insulin sensitivity. A: Intraperitoneal.

Effect of cold exposure on determinants of glucose tolerance.

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

Human IL-10 neutralization results in inhibited expression of intragraft Treg function genes and production of suppressive cytokine IL-10. Human IL-10.

Metabolic effects of VSG in GLP-1r KO mice.

Expression of PKCδ in islets and other tissues of control and PKCδKN-overexpressing mice. Expression of PKCδ in islets and other tissues of control and.

Average percent change in serum leptin and soluble leptin receptor (sOB-R) levels in response to rhLeptin administration at a low dose (0.01 mg/kg) (n.

β-Cell–specific deletion of Phb2 renders mice diabetic.

Increased pancreatic insulin content and islet size and protection against HFD- and palmitate-induced cell death in PKCδKN-overexpressing mice. Increased.

Chronic rapamycin treatment impairs β-cell mass and insulin clearance in rats. Chronic rapamycin treatment impairs β-cell mass and insulin clearance in.

Assessing the effect of TNF-α and TRAIL on A2-PPI15–24 CD8 T-cell cytotoxicity. Assessing the effect of TNF-α and TRAIL on A2-PPI15–24 CD8 T-cell cytotoxicity.

IL-1R deficiency does not protect syngeneic grafts from destruction.

Metabolic parameters in the three groups of patients during l-arginine infusion. Metabolic parameters in the three groups of patients during l-arginine.

Cytokine changes in LPS-induced TNFα and spontaneous IL-6 production in whole-blood cultures. Cytokine changes in LPS-induced TNFα and spontaneous IL-6.

RBP4 and glucose metabolism.

AEA and URB597 reduce MCP-2, IL-6, and IL-8 levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. AEA and URB597 reduce MCP-2, IL-6, and IL-8 levels.

IL6 mRNA is not detected in metastatic prostate cancer cells.

Results supporting the validity of TEF as a descriptor of posttransplant β-cell secretion. Results supporting the validity of TEF as a descriptor of posttransplant.

Distribution of daily frequency of BGM

ORs estimates for ER breast cancer subtypes in postmenopausal women ccording to tertiles of sex steroid hormone and SHBG levels. ORs estimates for ER breast.

Distributions of CD4, Th1, and Th2 in adults (n = 16; A) and children (n = 50; B). Distributions of CD4, Th1, and Th2 in adults (n = 16; A) and children.

Tumor and serum levels of murine IL-12.

Nested RT-PCR of Mammaglobin and CK19 mRNA in plasma and circulating cells of controls (C) and patients (T) with breast cancer. Nested RT-PCR of Mammaglobin.

Γ-TmT reduces serum E2 levels and induces estrogen-metabolizing enzyme CYP1A1 in E2-treated ACI rats. γ-TmT reduces serum E2 levels and induces estrogen-metabolizing.

Phenotypic and functional characteristics of PD-1hi B cells in HCC tissue. Phenotypic and functional characteristics of PD-1hi B cells in HCC tissue. A,

Posttransplantation cumulative survival for adult living-donor liver transplantation (LDLT) recipients without thrombotic microangiopathy (TMA; n = 220)

Presentation transcript:

Biomarkers detected in the serum of rat recipients of intraomental biologic scaffold and intrahepatic syngeneic islets. Biomarkers detected in the serum of rat recipients of intraomental biologic scaffold and intrahepatic syngeneic islets. Aliquots of 1,300 IEQ from the same syngeneic donor rat islet batch were transplanted in parallel either within the intraomental biologic scaffold (omentum [○]) or the intrahepatic site (liver [●]). Blood samples were collected from indwelling JVC for detection of biomarker levels in circulation. Data presented are mean ± SEM (n = 4–7 per time point). A and B: Metabolic markers assessed at 1 h posttransplant. A: Insulin in μg/mL (*P = 0.018). B: C-peptide in μg/mL. Inflammation markers assessed 24 h posttransplant: MCP-1/CCL2 in pg/mL (C), IL-6 in pg/mL (D), leptin in pg/mL (*P = 0.013) (E), haptoglobin in μg/mL (F), and α2-macroglobulin in μg/mL (**P < 0.03) (G). Dora M. Berman et al. Diabetes 2016;65:1350-1361 ©2016 by American Diabetes Association