1. Therapies For T1D Insulin therapy Transplantation Islet Encapsulation

8. Subcutaneous

15. Islet Transplantation

18. 600 500 400 300 200 100 2 4 6 810 122 46 810 600 500 400 300 200 100 0 12 a.m.p.m. Post-transplant Pre-transplant Time of day Blood glucose (mg/dl) Shapiro et al. N Engl J Med 2000; 343:230-238

24. Islet Encapsulation

25. Aileen King Structure of an Alginate Microcapsule

26. Aileen King Production of alginate/poly-L-lysine/alginate capsules

27. Aileen King Cells attached to the surface of capsules (A) and fibre production by cells on the capsule (B).

28. Igor Lacik

30. Long-Term Graft Function of Adult Rat and Human Islets Encapsulated in Novel Alginate- Based Microcapsules After Transplantation in Immunocompetent Diabetic Mice S Schneider, P. Feilen, F Brunnenmeier, T Minnemann, H Zimmermann, U Zimmermann, and M M. Weber Diabetes 54:687–693, 2005

31. Nonencapsulated and encapsulated adult rat islets

32. Nonencapsulated and encapsulated adult human islets