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Chronic brain insulin infusion reduces liver TG content independent of changes in body weight and food intake. Chronic brain insulin infusion reduces liver.

Published byRalf Barnett Modified over 5 years ago

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Presentation on theme: "Chronic brain insulin infusion reduces liver TG content independent of changes in body weight and food intake. Chronic brain insulin infusion reduces liver."— Presentation transcript:

1 Chronic brain insulin infusion reduces liver TG content independent of changes in body weight and food intake. Chronic brain insulin infusion reduces liver TG content independent of changes in body weight and food intake. A: Study protocol. MRT I–III indicate the time points where 1H-MRS measurements were performed. B: Liver fat content measured using 1H-MRS in anesthetized rats on days −3, 8, and 28. C: FA profiles from liver tissue harvested on day 30. Data are depicted as % change vs. vehicle-infused animals. D: Body weight. E: Food intake. F: Comparison of mRNA copy numbers of DNL genes in liver tissue samples from intracerebroventricular (ICV) insulin– or vehicle–treated rats. All error bars are SEM. *P < 0.05, **P < 0.01, ***P < vs. respective control group. n = 8/group. Thomas Scherer et al. Diabetes 2016;65: ©2016 by American Diabetes Association

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