CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional profile. CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional.

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CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional profile. CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional profile. Whole-transcriptome profiling by RNA-seq was performed on sorted CLA+ T cell subsets from blood or skin. (A) Venn diagram showing the number of significantly differentially expressed genes [FDR < 0.05 and log2 fold change (FC) > 1] between CLA+CD103+ T cells and either CLA+CD103−CCR7+ or CLA+CD103−CCR7− T cells as indicated. The overlapping 83 genes were designated as the CD103+ gene signature. (B) Barcode plot showing the distribution of the CD103+ signature genes (red, up-regulated in CD103+; blue, down-regulated in CD103+) relative to gene expression changes comparing CD103+ and CD103−CCR7− T cells from the blood or skin as indicated. Significance was determined by rotation gene set testing for linear models. (C) Heat map and hierarchical clustering of RNA-seq samples from the indicated blood and skin cell populations based on the CD103+ gene signature. (D) Venn diagram showing functional annotation of key genes up- or down-regulated by CLA+CD103+ T cells in blood or skin identified in our phenotypic, functional, and transcriptional analyses. Category names were assigned on the basis of described functions of the indicated genes in the published literature. Underlined gene names indicate proteins whose expression pattern was validated by flow cytometry in Figs. 3 and 5. Maria M. Klicznik et al. Sci. Immunol. 2019;4:eaav8995 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works