Volume 124, Issue 5, Pages (May 2003)

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Volume 124, Issue 5, Pages 1188-1192 (May 2003) Hyperleptinemia prevents increased plasma ghrelin concentration during short-term moderate caloric restriction in rats Rocco Barazzoni, Michela Zanetti, Marco Stebel, Gianni Biolo, Luigi Cattin, Gianfranco Guarnieri Gastroenterology Volume 124, Issue 5, Pages 1188-1192 (May 2003) DOI: 10.1016/S0016-5085(03)00281-6

Figure 1 Changes in (A ) body weight and (B ) food intake in the 3 groups during the 7-day study period. (A ) Day 6 and 7, leptin < control, P < 0.05. (B ) ∗P < 0.05. Leptin and pair fed vs. control. Gastroenterology 2003 124, 1188-1192DOI: (10.1016/S0016-5085(03)00281-6)

Figure 2 Effects of leptin and caloric restriction on plasma ghrelin concentration. Bars represent average ± standard error of values from 7 or 8 animals per group. ANOVA among groups, P = 0.0003. ∗Indicates statistical difference from control and leptin using Bonferroni correction comparing different subgroups (P < 0.005). Gastroenterology 2003 124, 1188-1192DOI: (10.1016/S0016-5085(03)00281-6)

Figure 3 (A ) Correlation between plasma ghrelin concentration and body weight changes during 1 week in the pair-fed calorie-restricted (○) and control (□) rats. A statistically significant negative correlation was also observed in the calorie-restricted group considered separately (R = −0.74; P < 0.05). (B ) Correlation between plasma ghrelin concentration and body weight changes during 1 week in the leptin-treated rats. Gastroenterology 2003 124, 1188-1192DOI: (10.1016/S0016-5085(03)00281-6)