Splicing and Dicing MYC-Mediated Synthetic Lethality

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Splicing and Dicing MYC-Mediated Synthetic Lethality Zachary E. Stine, Chi V. Dang Cancer Cell Volume 28, Issue 4, Pages 405-406 (October 2015) DOI: 10.1016/j.ccell.2015.09.016 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 The BUD31 Dependent Core Spliceosome Catalyzes the Removal of Introns from pre-mRNA MYC activation increases transcription, causing dependence on the core spliceosome. Core spliceosome inhibition causes increases intron retention resulting in apoptosis in MYC activated cells but not in cells lacking MYC activation. Cancer Cell 2015 28, 405-406DOI: (10.1016/j.ccell.2015.09.016) Copyright © 2015 Elsevier Inc. Terms and Conditions