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AML Therapy: Wake Up the Guardian and Cut Loose the Executioners

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Presentation on theme: "AML Therapy: Wake Up the Guardian and Cut Loose the Executioners"— Presentation transcript:

1 AML Therapy: Wake Up the Guardian and Cut Loose the Executioners
Dario C. Altieri  Cancer Cell  Volume 32, Issue 6, Pages (December 2017) DOI: /j.ccell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Antileukemic Effect of the Combination of Venetoclax Plus RG7388 Simultaneous inhibition of Bcl-2/Bax-Bak complexes (Venetoclax) and reactivation of p53 tumor suppressor function (RG7338) results in kinase-dependent destabilization and proteasomal destruction of anti-apoptotic Bcl-2 family protein, Mcl-1, oligomerization of Bax at the outer mitochondrial membrane, and activation of apoptosis. Cancer Cell  , DOI: ( /j.ccell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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