SIRT1 is downregulated in human gastric cancer (GC).

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SIRT1 is downregulated in human gastric cancer (GC). SIRT1 is downregulated in human gastric cancer (GC). A–C, normal and GC tissue specimens were analyzed for SIRT1 expression using immunohistochemistry. SIRT1 expression is stained in brown and the cell nuclei were counterstained with hematoxylin (blue). Original magnification, ×400. Scale bars, 20 μm. D, qRT-PCR analysis of SIRT1 mRNA in normal and the matched GC tissues. Data, mean ± SD. Qing Yang et al. Mol Cancer Res 2013;11:1497-1507 ©2013 by American Association for Cancer Research