Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. (A)

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Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. (A) Day 12 B16.F10-OVA tumor volumes (left) and animal survival (right) of mice with varying Batf3 genotypes after necroptotic fibroblast injections. n = 4 to 12 mice per group. d.11, day 11. (B) B16.F10-OVA tumor growth (left) and animal survival (right) upon coadministration of necroptotic fibroblasts with depleting antibodies against either CD4+ or CD8+ leukocytes. n = 6 to 11 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. Black arrows indicate intratumoral dying cell injections. Error bars represent SEM. Data are pooled from two to four independent experiments. Annelise G. Snyder et al. Sci. Immunol. 2019;4:eaaw2004 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works