Model of EphA/ephrin-A expression in GBM. Figure 1 from B W Day British Journal of Cancer (2014) 111, 1255-1261; doi:10.1038/bjc.2014.73 Several approaches exist to target Eph receptors. Kinase inactivating strategies include kinase inhibitors or blocking peptides or antibodies. Kinase activating strategies include ligand stimulation, activating antibodies or ligand peptide mimetics Strategies to deliver toxic payloads following receptor activation and internalisation include coupling of cytotoxic agents or radionuclides to Eph monoclonal antibodies. © 2014 Cancer Research UK.