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Inhibitor of MAP kinase activation blocks colon cancer growth

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Presentation on theme: "Inhibitor of MAP kinase activation blocks colon cancer growth"— Presentation transcript:

1 Inhibitor of MAP kinase activation blocks colon cancer growth
Dan Gordon  Gastroenterology  Volume 117, Issue 3, (September 1999) DOI: /S (99) Copyright © Terms and Conditions

2 Fig. 1 PD , a potent, highly specific, and orally active inhibitor of MEK (MAP kinase kinase) acts at a critical convergence point through which receptor tyrosine kinases (RTK) and G protein-coupled receptors (GPCR) activate MAP kinase and stimulate multiple downstream effects including tumor cell proliferation. Gastroenterology  , DOI: ( /S (99) ) Copyright © Terms and Conditions


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