Highly related T9 and T3 sarcoma cells show distinct tumor growth patterns but similar PD-L1 expression kinetics in vivo. Highly related T9 and T3 sarcoma.

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Presentation transcript:

Highly related T9 and T3 sarcoma cells show distinct tumor growth patterns but similar PD-L1 expression kinetics in vivo. Highly related T9 and T3 sarcoma cells show distinct tumor growth patterns but similar PD-L1 expression kinetics in vivo. Top, In vivo tumor growth of unedited T9 and edited T3 sarcoma clones in naïve syngeneic 129S6 strain WT mice. Groups of 5 mice bearing T9 sarcoma cells were left untreated. Groups of 5 mice bearing T3 sarcoma cells were left untreated or treated with anti–PD-1 (RMP1–14) or anti–PD-L1 mAb (10F.9G2). Data are shown by mean ± SEM from at least two independent experiments. Bottom, Numbers of PD-L1 molecules on tumor (CD45−) and immune cells (CD45+) in vivo. Data are shown by mean ± SEM from two independent experiments (n = 4). Takuro Noguchi et al. Cancer Immunol Res 2017;5:106-117 ©2017 by American Association for Cancer Research