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Immune checkpoint molecule expression in primary and secondary tumors following radiotherapy. Immune checkpoint molecule expression in primary and secondary.

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Presentation on theme: "Immune checkpoint molecule expression in primary and secondary tumors following radiotherapy. Immune checkpoint molecule expression in primary and secondary."— Presentation transcript:

1 Immune checkpoint molecule expression in primary and secondary tumors following radiotherapy.
Immune checkpoint molecule expression in primary and secondary tumors following radiotherapy. On day 8 after injection of both primary and secondary B16-OVA tumor cells (2 × 105), primary tumors of the right hindlimb were irradiated with a single dose of 15 Gy. In the following weeks, TILs were isolated and analyzed for PD-1 expression (A) and CTL function (B) of CD11ahigh CD8+ T cells. Data show percentages of PD-1+ in total CD11ahigh CD8+ TILs of 3 to 5 mice per group. *, P < 0.05; **, P < 0.01, compared with that in mice without radiotherapy (A). Arrow indicates day of radiotherapy (day 8). The production of IFNγ was analyzed by intracellular staining for IFNγ after a brief restimulation with OVA peptide ex vivo for 5 hours. Numbers in parentheses show the percentages of IFNγ-producing cells per PD-1+ population. C, B7-H1 (PD-L1) expression by CD45− (tumor cells) and CD45+ (leukocytes) cells within both tumor sites. D, LAG-3 and Tim-3 expression by CD11ahigh or CD11alow CD8+ TILs within both tumor sites. Sean S. Park et al. Cancer Immunol Res 2015;3: ©2015 by American Association for Cancer Research

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