Terry A. Ring Chemical Engineering University of Utah AIChE Contest Week 1 Terry A. Ring Chemical Engineering University of Utah

Reminder Planning Memo Due Friday

Questions Posed during the week We want to enter the contest. What do we do? All teams and individuals are performing their work under contest rules All teams and individuals are entering the contest at the UoU. 2 Teams and 2 Individuals will be sent into the National Contest from UoU Can you help with “The secret's out: Clean-in-Place” Article in Chemical Engineering? It is behind a pay wall. See 2008 Book in canvas from  Dale A. Seiberling, the author of the 1996 Chemical Engineering Article, on Clean-in-Place. It is much more complete than the Chemical Engineering Article

Questions Would it be appropriate to notify students of a good book? 1st Edition (2009) and 2nd Edition (2017) Available electronically at Marriott Library

Clean-in-Place Overview Clean-in-place (CIP) is a cleaning method used mainly in the pharmaceutical manufacturing industry. CIP can be implemented to clean vessels, interior surfaces of pipes, filters, process equipment, and fittings, without disassembly.

Clean-in-Place Phases Rinse Phase (High Pressure Wash) Gas Blow Phase Intermediate Drain Phase Chemical Wash Phase May have several chemicals used in sequence or all-in-one Surfactants, oxidizers, Acid, Base, chelating agents, corrosion inhibitors, defoamers Temperature has an impact on Cleaning (viscosity, Rxn Rate, Melt Fats) Steam can be used. Final Rinse Phase Final Drain Phase Stand-by Phase

Clean-In-Place Water The water used to clean pharmaceutical production equipment must be as high quality as the water used for production. This means purified water capacity must be sufficient to meet the needs of cleaning, in addition to production volume. Typically, systems are also taken apart twice a year for cleaning, utilizing chemicals stronger than those of the typical CIP cleaning cycle. As an integration company with over 30 years of pharmaceutical industry experience, Grantek provides end-to-end services to ensure our customers’ purified water systems are installed and integrated into the facility in accordance with current industry standards.

CIP Water Treatment A typical system that produces purified water may require three stages: 1) Pretreatment, consisting of filtration to remove particulates and some organics, and de-chlorinization to remove chlorine added by the municipal water treatment system. Chlorine will degrade stainless steel over time and therefore must be removed from the water before the water enters the pharmaceutical production equipment. Activated carbon filters are typically used to remove chlorine, which can also damage reverse osmosis (RO) membranes over time. Sediment filters may be used to remove particulates.

CIP Water Treatment 2) Final treatment, in which the water is purified via ion exchange, RO, electro deionization, or a combination of methods. Disinfection methods include RO and continuous electro deionization (CEDI), which uses electricity, ion exchange membranes, and resin to deionize water. CEDI does not require the use of chemical treatments. 3) Polishing steps, including electrodeionization (EDI), which is usually a polishing treatment to RO. Continuous EDI units use the electric current to regenerate the resin mass continuously. This technique can achieve very high purity, with conductivity below 0.1 µS/cm. Ultraviolet light systems leave no residue in the water and deactivate the DNA of bacteria and viruses that may be present. A typical WFI production system consists of a water purification system, distillation equipment, and storage tanks specifically for WFI.

1000 L Bio Reactor

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