Madeira, Teixeira, Sa-Correia, Oliveira TCBB Volumn 7(1) 2010

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Presentation transcript:

Madeira, Teixeira, Sa-Correia, Oliveira TCBB Volumn 7(1) 2010 Indentification of Regulatory Modules in Time Series Gene Expression Data Madeira, Teixeira, Sa-Correia, Oliveira TCBB Volumn 7(1) 2010

Introduction Given a set of genes (rows) for a serious of event (column), biclustering identifies a subset of genes and events that have the same behaviour. Biclustering is NP-Hard. In time series data, one can assume the “event” have to be contiguous columns.

Process Data discretization, transform data from expression to discrete values (up, down, no change) Identify maximal biclusters. Filter biclusters base on statistical significance. Filter base on overlap

Data Discretization

Statistical Significance & Similarity

Generated Data

Yeast Data

Up Regulation

Down Regulation