Kinase signaling and targeted therapy for primary myelofibrosis

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Presentation transcript:

Kinase signaling and targeted therapy for primary myelofibrosis Qiong Yang, John D. Crispino, Qiang Jeremy Wen Experimental Hematology Volume 48, Pages 32-38 (April 2017) DOI: 10.1016/j.exphem.2016.12.007 Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions

Figure 1 Important pathways in the development of megakaryocytes. Aurora A kinase, JAK-STAT, and RhoA/ROCK are important pathways regulating the proliferation, survival, differentiation, enomitosis, and proplatelet formation of megakaryocytes. Mutations of proteins are indicated by stars. Experimental Hematology 2017 48, 32-38DOI: (10.1016/j.exphem.2016.12.007) Copyright © 2016 ISEH - International Society for Experimental Hematology Terms and Conditions