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Volume 73, Issue 8, Pages (April 2008)

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Presentation on theme: "Volume 73, Issue 8, Pages (April 2008)"— Presentation transcript:

1 Volume 73, Issue 8, Pages 903-905 (April 2008)
Connecting the interpodocyte slit diaphragm and actin dynamics: Emerging role for the nephrin signaling complex  S. Lehtonen  Kidney International  Volume 73, Issue 8, Pages (April 2008) DOI: /ki Copyright © 2008 International Society of Nephrology Terms and Conditions

2 Figure 1 Signaling complexes regulating actin dynamics in the slit diaphragm. Several transmembrane proteins in the slit diaphragm associate with the actin cytoskeleton either directly or indirectly via cytosolic scaffolding proteins. Phosphorylation of the nephrin–NEPH1 protein complex activates signaling pathways that cooperatively modulate actin organization in podocytes. FAT1 also associates with proteins that regulate actin polymerization. Kidney International  , DOI: ( /ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions


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