A Swiss Army Knife to Cut Malaria Transmission Mathilde Gendrin  Cell Host & Microbe  Volume 22, Issue 5, Pages 577-579 (November 2017) DOI: 10.1016/j.chom.2017.10.016 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Strategies Proposed in the Highlighted Studies to Limit Malaria Transmission Using the Mosquito Microbiota (A) Transmission-blocking strategies involved in the studies of Pike et al. (2017) on genetically modified (GM) mosquitoes and of Wang et al. (2017) on GM bacteria from the microbiota. (B) Inheritance of a malaria-blocking transgene may be increased by gene drive or microbiota-mediated preference to cross-mating versus assortative mating. Starting with a population where 10% of males and 10% of females are heterozygous transgene carriers (first generation after crossing WT and homozygous transgene carriers), 9.75% of the progeny are expected to carry the transgene according to Mendelian inheritance. Gene drive leads to an increase in the chance of transmission, resulting in up to 19% of the progeny carrying the transgene. Microbiota-mediated shift in mating preference is less quantifiable, but decreases the chance of WT by WT crosses. As these crosses are the most frequent, the effect on transgene inheritance is significant. The transgene and WT homologous loci are represented in green and white, respectively. Cell Host & Microbe 2017 22, 577-579DOI: (10.1016/j.chom.2017.10.016) Copyright © 2017 Elsevier Inc. Terms and Conditions