1. HIV Latency Gets a New Histone Mark
Bryan C. Nikolai, Qin Feng 
Cell Host & Microbe 
Volume 21, Issue 5, Pages (May 2017)
DOI: /j.chom
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Chromatin Modifiers as Potential Therapeutic Targets for Reversing HIV Latency
Chromatin modifiers including “writer,” “reader,” and “eraser” are involved in HIV-1 latency. “Writer” is an enzyme that covalently modifies histones or DNA. “Reader” can specifically recognize chromatin modifications, whereas “eraser” can remove modifications. The Boehm et al. (2017) study indicates that SMYD2, and likely L3MBTL1, are novel regulators and pharmacological targets of HIV-1 latency. Epigenetic events under the control of host cell coregulators of HIV transcription and latency are of particular interest for “shock and kill” approaches of HIV-1 eradication for a functional cure.
Cell Host & Microbe  , DOI: ( /j.chom )
Copyright © 2017 Elsevier Inc. Terms and Conditions