The Biologic Basis of Migraine

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Presentation transcript:

The Biologic Basis of Migraine

Migraine Is Inherited

Atypical Activation Patterns in the Migraine Brain in Response to Visual, Olfactory, and Painful Stimuli

Migraine Multiphasic Paroxysmal Neurologic Disorder

Migraine Attack Begins With Activation of the Hypothalamus and Functional Coupling Between Hypothalamus and Trigeminal Nucleus

Aura Phase Involves a Cortical Spreading Depolarization (Depression) and Secondary Blood Flow Changes

Aura Results in Activation of Peripheral Trigeminal Sensory Pain Fibers and Central Trigeminovascular System

The Anatomy of Migraine Headache

Postdrome Unlike Prodrome Phase, Is Associated With a Global Reduction in Cerebral Blood Flow

Triptans Selective 5-HT1B/1F Receptor Agonists

Trigeminal Sensory Fiber Activation and CGRP

Understanding the Biologic and Molecular Bases Unveils Unique Therapeutic Targets

Abbreviations

Abbreviations (cont)