6. Asthma Journal of Allergy and Clinical Immunology

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Presentation transcript:

6. Asthma Journal of Allergy and Clinical Immunology Robert F. Lemanske, MD, William W. Busse, MD Journal of Allergy and Clinical Immunology Volume 111, Issue 2, Pages S502-S519 (February 2003) DOI: 10.1067/mai.2003.94 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 One mechanism that initiates airway inflammation in antigen exposure in sensitized individuals. Antigen interaction with mast cell-bound, specific-IgE antibody results in release of preformed (histamine) and generated (leukotrienes) mediators along with cytokines [interleukins -4 and -5 and granulocyte macrophage-colony stimulating factor (GM-CSF)]. These various compounds can induce localized inflammatory cell influx and activation through the upregulation of various chemokines and adhesion molecules and recruitment of bone marrow cells (eg, eosinophils). (Modified and reproduced with permission from Busse WW, Lemanske RF Jr. N Engl J Med 2001;344:350-62.) Journal of Allergy and Clinical Immunology 2003 111, S502-S519DOI: (10.1067/mai.2003.94) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Stepwise approach for treating infants and young children (5 years of age and younger) with acute or chronic asthma (reproduced from www.nhlbi.nih.gov/guidelines/asthma/asthsumm.htm ). Journal of Allergy and Clinical Immunology 2003 111, S502-S519DOI: (10.1067/mai.2003.94) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 Stepwise approach for treating asthma in adults and children older than 5 years of age (reproduced from www.nhlbi.nih.gov/guidelines/asthma/asthsumm.htm ). Journal of Allergy and Clinical Immunology 2003 111, S502-S519DOI: (10.1067/mai.2003.94) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 4 Dosages for long-term control medications (reproduced from www.nhlbi.nih.gov/guidelines/ asthma/asthsumm.htm). Journal of Allergy and Clinical Immunology 2003 111, S502-S519DOI: (10.1067/mai.2003.94) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 5 Estimated comparative daily dosages of inhaled corticosteroids (reproduced from www.nhlbi.nih.gov/guidelines/asthma/asthsumm.htm ). Journal of Allergy and Clinical Immunology 2003 111, S502-S519DOI: (10.1067/mai.2003.94) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 6 Estimated severity of asthma exacerbations (reproduced from Murphy S, Bleecker ER, Boushey H, et al, editors. Guidelines for the diagnosis and management of asthma. National Asthma Education and Prevention Program. II, 1-150. 1997. Bethesda, Md: National Institutes of Health). Journal of Allergy and Clinical Immunology 2003 111, S502-S519DOI: (10.1067/mai.2003.94) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 7 Home treatment of asthma exacerbations (reproduced from Murphy S, Bleecker ER, Boushey H, et al, editors. Guidelines for the diagnosis and management of asthma. National Asthma Education and Prevention Program. II, 1-150. 1997. Bethesda, Md: National Institutes of Health). Journal of Allergy and Clinical Immunology 2003 111, S502-S519DOI: (10.1067/mai.2003.94) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 8 Hospital-based treatment of asthma exacerbations (reproduced from Murphy S, Bleecker ER, Boushey H, et al, editors. Guidelines for the diagnosis and management of asthma. National Asthma Education and Prevention Program. II, 1-150. 1997. Bethesda, Md: National Institutes of Health). Journal of Allergy and Clinical Immunology 2003 111, S502-S519DOI: (10.1067/mai.2003.94) Copyright © 2003 Mosby, Inc. Terms and Conditions