Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients: a pragmatic randomized clinical trial  B.F. Riecke, R. Christensen, P. Christensen, A.R. Leeds, M. Boesen, L.S. Lohmander, A. Astrup, H. Bliddal  Osteoarthritis and Cartilage  Volume 18, Issue 6, Pages 746-754 (June 2010) DOI: 10.1016/j.joca.2010.02.012 Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Progress of participants through CAROT-study. Abbreviations: ITT, Intention-to-treat population. Osteoarthritis and Cartilage 2010 18, 746-754DOI: (10.1016/j.joca.2010.02.012) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Clinical efficacy following 16 weeks therapy. A: Proportion of patients loosing ≥10% of their body weight after 8 and 16 weeks. B: Proportion of patients responding to therapy according to the OMERACT–OARSI responder criterion after 8 and 16 weeks. ▴=VLED, ■=LED. A response according to the guidelines of the OMERACT–OARSI was classified as a high improvement in pain or function (≥50%) and an absolute change≥20%, or an improvement in at least 2 of the 3 following: pain≥20% and absolute change≥10%; function≥20% and absolute change≥10%; patient's global assessment≥20% and absolute change≥10%. Osteoarthritis and Cartilage 2010 18, 746-754DOI: (10.1016/j.joca.2010.02.012) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions