Figure 2 Embryonic origins of tissue-resident macrophages

Slides:

Advertisements

Similar presentations

Microglia are tissue-resident macrophages in the CNS.

Advertisements

Pluripotent stem cell based gene therapy for hematological diseases

Primitive Macrophages Drive Coronary Development

Figure 3 Life expectancy at birth in all countries included

Figure 1 Lymphocytes during the disease

Figure 3 Example of how a noncoding regulatory rheumatoid

Figure 1 Historical evolution of the clinical classification and

Figure 2 Representative MSI data obtained from human joints

Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Enthesitis versus synovitis

Nat. Rev. Rheumatol. doi: /nrrheum

PART 1 Basic Embryology.

The embryonic origins of erythropoiesis in mammals

Figure 1 Factors underlying metabolic alterations in osteoarthritis

Nat. Rev. Rheumatol. doi: /nrrheum

by Joanna Tober, Kathleen E. McGrath, and James Palis

Figure 1 Old age, metabolites, and chronic inflammation

Figure 4 Ex vivo synovial tissue culture viability

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Targeted versus untargeted metabolomics approaches

Figure 1 Metabolic profiling as a tool for studying rheumatic diseases

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Simplified EULAR and GRAPPA

Figure 3 Transcriptome studies performed in the target

Figure 2 Shared genetic loci in systemic autoimmune diseases

Globin Gene Expression Is Reprogrammed in Chimeras Generated by Injecting Adult Hematopoietic Stem Cells into Mouse Blastocysts Hartmut Geiger, Stefanie.

Taking Advantage of the Systemic Immune System to Cure Brain Diseases

Figure 1 Location of HLA variants known to be associated

Figure 1 Physiological metabolism of Aβ in the brain and periphery

Figure 1 A schematic representation of the role

Figure 2 Interaction effects between heterozygous HLA‑DRB1

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Microbiota and osteoimmunology

Figure 3 Statistical approaches for the analysis of metabolomic data

Figure 3 Cell-surface markers for NP cell differentiation

Figure 6 Lack of IRF5 causes a reduction in neutrophil influx

Figure 5 The role of Ly6Chi and Ly6Clo monocytes

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Multi-hit model for autoimmune diseases

Nat. Rev. Rheumatol. doi: /nrrheum

Hematopoiesis from embryonic stem cells: lessons from and for ontogeny

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Emerging hallmarks of T cells in rheumatoid arthritis

Yolk-sac hematopoiesis

Figure 6 Vascular dysfunction in epilepsy

Origin and Functions of Tissue Macrophages

Figure 2 Developmental and alternative sources of fibroblasts

Nat. Rev. Rheumatol. doi: /nrrheum

The ontogeny of hematopoiesis in zebrafish.

Jianpeng Sheng, Christiane Ruedl, Klaus Karjalainen Immunity

Figure 8 HRQOL in individuals with RA

Figure 6 Metabolism of pterins

Figure 1 Reproductive health in patients with rheumatic diseases

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 GM-CSF — a key player in inflammation and autoimmunity

Nat. Rev. Rheumatol. doi: /nrrheum

Tissue-Resident Macrophage Ontogeny and Homeostasis

Figure 3 Nuclear-penetrating autoantibodies and synthetic lethality

Figure 1 Overall worldwide prevalence ranges for SLE

Figure 2 Phenotypes of osteoarthritis

Sublime Microglia: Expanding Roles for the Guardians of the CNS

Microglia: Multitasking Specialists of the Brain

Figure 1 Patterns of joint and organ involvement in rheumatic disease

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 The role of macrophages in RA

Figure 1 Monocyte and macrophage ontogeny

Shifts in site of hematopoiesis during mouse and human development.

Lung macrophage development and composition through the lifespan.

Presentation transcript:

Figure 2 Embryonic origins of tissue-resident macrophages Figure 2 | Embryonic origins of tissue-resident macrophages. The majority of tissue-resident macrophages are seeded during embryonic development. Yolk-sac macrophages arise first from primitive haematopoiesis and seed embryonic tissues, including the brain, as early as day E9.0. A wave of yolk-sac-derived erythromyeloid progenitors (EMPs) seeds the fetal liver, where definitive haematopoiesis is established on E11.0. The fetal liver is the main site of haematopoiesis until birth. On E12.5, fetal-liver-derived monocytes populate the embryo and dilute the yolk-sac-derived populations. However, yolk-sac macrophages remain the sole source of microglia, the brain's resident macrophages, probably because of the establishment of the blood–brain barrier. In the epidermis and pancreas, macrophages seem to have a hybrid origin, arriving in both yolk-sac and fetal-liver waves. In other tissues, resident macrophages are exclusively derived from fetal-liver monocytes. The fate mapping of tissue-resident synovial macrophages has not yet been done. Udalova, I. A. et al. (2016) Macrophage heterogeneity in the context of rheumatoid arthritis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.91