Interleukin-18: The Bouncer at the Mucosal Bar

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Interleukin-18: The Bouncer at the Mucosal Bar Timothy W. Hand Cell Volume 163, Issue 6, Pages 1310-1312 (December 2015) DOI: 10.1016/j.cell.2015.11.041 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Role of Inflammasome and IL-18 in Barrier Function (A) At steady state, a healthy bacterial microbiota produces metabolites, such as taurine, that support inflammasome-mediated production of IL-18 and anti-microbial proteins in the colon that promote microbial diversity and prevent commensal dysbiosis. (B) A dysbiotic microbiota is characterized by different metabolites, such as spermine, that inhibit the inflammasome and inhibit anti-microbial protein production, allowing for its invasive character. During inflammation-induced colitis, IL-18 prevents the development of goblet cells from uncommitted precursors, significantly reducing mucus production and intestinal barrier function. Cell 2015 163, 1310-1312DOI: (10.1016/j.cell.2015.11.041) Copyright © 2015 Elsevier Inc. Terms and Conditions