1. Microbial Molecules from the Multitudes within Us
Matthew R. Redinbo 
Cell Metabolism 
Volume 25, Issue 2, Pages (February 2017)
DOI: /j.cmet
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
GI Microbiota Encode Biosynthetic Pathways Capable of Creating Molecules that Act on Human Targets
The human gastrointestinal (GI) microbiota (left) encode nonribosomal peptide synthetase (NRPS) biosynthetic clusters that, when expressed in vitro in common laboratory bacteria (Escherichia coli, Bacillus subtilis), create novel metabolites. The compounds synthesized are structurally akin to human drugs and can inhibit human proteins, like the cathepsin proteases. Future questions include what other chemicals are manufactured by our microbiota (red), what signals the microbiota to create these compounds (blue), and what other human and bacterial targets do the compounds hit (green)?
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2017 Elsevier Inc. Terms and Conditions