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Stop Press: Eosinophils Drafted to Join the Th17 Team

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Presentation on theme: "Stop Press: Eosinophils Drafted to Join the Th17 Team"— Presentation transcript:

1 Stop Press: Eosinophils Drafted to Join the Th17 Team
Simon Keely, Paul S. Foster  Immunity  Volume 43, Issue 1, Pages 7-9 (July 2015) DOI: /j.immuni Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 The Role of Eosinophils in IL-23-GM-CSF-Eosinophil-Driven Inflammation IL-5 is the major mediator of eosinophilic disease in allergy. IL-5 promotes eosinophil release from the bone marrow and enhances eosinophil response to eotaxin while Th2 cell cytokines sustain eosinophil activation at the mucosa. In contrast, during colitis, IL-5 is required for eosinophil trafficking to the intestinal mucosa but eosinophil activation is sustained by GM-CSF secreted from Th17 cells. Immunity  , 7-9DOI: ( /j.immuni ) Copyright © 2015 Elsevier Inc. Terms and Conditions


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