Active avoidance is impaired in aged mice in both multimodal and visual versions of the task. Active avoidance is impaired in aged mice in both multimodal.

Slides:

Advertisements

Similar presentations

Impaired learning and relearning of virtual cued goal localization in Shank2-deficient mice. Impaired learning and relearning of virtual cued goal localization.

Advertisements

DH E2 infusion significantly increased phosphorylation of the p42 isoform of ERK (A) and of Akt (B) in the DH of OVX females, but not sham GDX males. DH.

The ERK phosphorylation inhibitor U0126 did not block the memory-enhancing effects of E2 in intact or GDX males. The ERK phosphorylation inhibitor U0126.

Peptidergic nociceptor markers are reduced in DRG from Nav-Tsc2 mice.

Fiber innervation is reduced in both central and peripheral targets of DRG neurons in Nav-Tsc2 mice. Fiber innervation is reduced in both central and peripheral.

A–E, Active avoidance (A–D) and optokinetic testing (E) in an independent cohort. A–E, Active avoidance (A–D) and optokinetic testing (E) in an independent.

Implicit adaptation generalizes around the aiming location (30° CCW)

Image resolution in cleared tissue.

qRT-PCR validation of differential expression.

Expression of Glasso network genes in PC12 cells.

Effects of E2 on levels of phospho-CREB in the DH of OVX females, sham males, and GDX males. Effects of E2 on levels of phospho-CREB in the DH of OVX females,

Neuronal ATM level is reduced in mouse models of AD

Learned helplessness assessed by active avoidance in dMHbCKO mice.

Changes in WM diffusion parameters with increasing age along the length of HG from medial (primary) to lateral (nonprimary). Changes in WM diffusion parameters.

Task involvement scales change-related potentials A–C, Change-time aligned, central potentials exhibited different profiles across task involvement. Task.

Firing rate following isolated, unreinforced lever presses.

Potency of menthol depends on L9´ residue size.

Loss of Cav1 function does not disrupt formation of dual projecting CPN/FPN axonal projections at P8. Loss of Cav1 function does not disrupt formation.

EEG-based classification accuracy for across- and within-expression discrimination of facial identity with temporally cumulative data (50–650 ms after.

The complexity as well as the total dendritic length of ApoE-deficient adult-born granule cells are significantly reduced. The complexity as well as the.

A, Rewarded voluntary switch task, a combined risky decision-making and task-switching paradigm. A, Rewarded voluntary switch task, a combined risky decision-making.

Altered luminal pH of the Golgi apparatus in GPHR deficient primary cultured neurons. Altered luminal pH of the Golgi apparatus in GPHR deficient primary.

Discriminating IR light with visual cortex.

Results of CFC training and testing.

APT1 palmitoylation and localization.

Effect of FGF8 on R-C marker expression.

Impairments of NMDA receptor-dependent hippocampal synaptic plasticity in DGCs in GirdinSA/SA and Girdin+/− mice. Impairments of NMDA receptor-dependent.

Log10-transformed EEG power in the 0- to 30-Hz range measured in females (white) and males (gray) at each channel for NFB (left) and CAL (right), shown.

The Fisher information predicts the experimentally measured sensitivity. The Fisher information predicts the experimentally measured sensitivity. A, Sensitivity.

Effects of MPH on 19 single neuron response metrics.

Learning rates and CR latency data for mice trained at trace 50–350 or trace 50–450. Learning rates and CR latency data for mice trained at trace 50–350.

IOP is not affected by microfibril deficiency.

Synaptic density is significantly impaired in male FBN-ARO-KO mice.

Frontal and occipital white matter/visuomotor gray matter.

Male FBN-ARO-KO mice exhibit cognitive defects but normal locomotor activity and anxiety levels. Male FBN-ARO-KO mice exhibit cognitive defects but normal.

Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. A,

MSK1 is necessary for BDNF-dependent CREB phosphorylation in area CA1.

Short-term synaptic depression in SCN neurons during stimulus train application. Short-term synaptic depression in SCN neurons during stimulus train application.

BNST AVP cell ablations did not change the ability to discriminate between social odors. BNST AVP cell ablations did not change the ability to discriminate.

Reduction of PGC-1α isoforms, SDHA, and Tomm20 in PD

Acquisition of trace 50–250 is dependent on a subregion of mPFC in mice. Acquisition of trace 50–250 is dependent on a subregion of mPFC in mice. A, CR.

LFP findings from the PPC during performance on the visual target-detection task. LFP findings from the PPC during performance on the visual target-detection.

Nicotine and amphetamine modify burst and pause activity.

Distribution of examined mRNAs across CeA subcompartments.

PTZ-induced neuronal activity visualized by IEGs

Brain selective uptake of CE from plasma HDL

Effects of pain-stress on striatal dopamine release as a function of HTR2C genotype. Effects of pain-stress on striatal dopamine release as a function.

Genetic inhibition of PKA in the adult impairs memory for contextual fear conditioning. Genetic inhibition of PKA in the adult impairs memory for contextual.

Use of a PPT to ascertain female preference for males previously exposed to PO relative to CO. A, Schematic representation of the T-maze used for the PPT.

Summary data for target shift experiments and transient recall of old memories observed in the second target shift task. Summary data for target shift.

Transgenic expression of mCREB or CREB produces opposite effects in the learned helplessness model of depression. Transgenic expression of mCREB or CREB.

Responses measured by BOLD fMRI in areas V1, V2, V3, and MT+ as two subjects (S2, gray; S3, black) switched between the speed and the contrast discrimination.

Impact of CMV congenital infection on olfactory discrimination in adult male mice. Impact of CMV congenital infection on olfactory discrimination in adult.

A, Cells present in clonal clusters were classified based on morphology (see Materials and Methods) into type 1 progenitor cells (A.1); type 2/3 progenitor.

A, B, Startle magnitude and PPI after treatment with CNO

Impact of CMV congenital infection on olfactory perception in adult male mice. Impact of CMV congenital infection on olfactory perception in adult male.

The repertoire of NPC-derived cells within the CC during cuprizone-induced demyelination. The repertoire of NPC-derived cells within the CC during cuprizone-induced.

Elimination of dendritic spines per 2 d.

Histology and task acquisition.

The dopamine (DA) response to cocaine infusion in the NAc in constitutive p11 KO mice is restored by nicotinic or muscarinic receptor stimulation in the.

Cue-evoked dopamine release dynamics in the NAc shell and core.

Associations between the differences in BDNF or TrkB mRNA expression and in GAD67 mRNA expression across subject pairs. Associations between the differences.

Effects of follicular depletion induced by VCD and chronic 17β-estradiol (E) administration on the relative mRNA expression of PR (left panel) and ERβ.

Power spectra of EMG during the pre- and post-feedback sessions.

Firing rate during consummatory behavior at the early training time point. Firing rate during consummatory behavior at the early training time point. Cells.

A, B, Transcription factor p65 (A) and p50 (B) DNA binding activity in hippocampal nuclear extracts of LD and DD mice. A, B, Transcription factor p65 (A)

Grand-averaged ERPs across (A) left hemisphere electrodes (P5, P7, P9, PO3, PO7, and O1) and (B) right hemisphere electrodes (P6, P8, P10, PO4, PO8, and.

The experimental chamber

A, The ratio of currents elicited by an EC50 concentration of ACh and 100 µm menthol over the current elicited by ACh alone. A, The ratio of currents elicited.

At P23, dendritic spine density on L2/3 pyramidal cells in PirB−/− visual cortex is similar to that of PirB+/+. At P23, dendritic spine density on L2/3.

Presentation transcript:

Active avoidance is impaired in aged mice in both multimodal and visual versions of the task. Active avoidance is impaired in aged mice in both multimodal and visual versions of the task. A, E, Percentage of successful avoidance trials is shown in blocks of 20 trials over the 2 day test period for the multimodal (A) and visual (E) version of the task. B, F, Slopes of the percentage of avoidance per trial are shown for the multimodal (B) and visual (F) AA task for both training days. C, D, G, H, The percentages of escapes (C, G) and escape failures (D, H) are shown in blocks of 20 trials over the 2 day test period for the multimodal (C, D) and visual (G, H) AA task. Values are expressed as the mean ± SEM (A, C, D, E, G, H) or box plots, as defined in the Data analysis section in Materials and Methods (B, F). *p < 0.05, **p < 0.005, ***p < 0.0001. Martin Weber et al. eneuro 2015;2:ENEURO.0047-15.2015 ©2015 by Society for Neuroscience