ILC1 Populations Join the Border Patrol

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ILC1 Populations Join the Border Patrol Kevin J. Maloy, Holm H. Uhlig Immunity Volume 38, Issue 4, Pages 630-632 (April 2013) DOI: 10.1016/j.immuni.2013.03.005 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 ILC1 Populations Contribute to Protection and Pathology in the Intestine Subsets of T-bet+IFN-γ+ ILC1 in the murine intestine include intraepithelial ILC1 that respond to IL-12 and IL-15, lamina propria ILC1 that respond to IL-12 and IL-18, and NK cells. RORγt+ ILC3 may switch toward T-bet+ ILC1 cells in response to environmental factors, such as IL-12. ILC1-derived Th1 cytokines may activate protective innate immunity but may also contribute to intestinal pathology. Immunity 2013 38, 630-632DOI: (10.1016/j.immuni.2013.03.005) Copyright © 2013 Elsevier Inc. Terms and Conditions