1. How Many Subsets of Innate Lymphoid Cells Do We Need?
Kafi N. Ealey, Shigeo Koyasu 
Immunity 
Volume 46, Issue 1, Pages (January 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1 Heterogeneity of ILCs in Mouse and Human Tissues
Simoni et al. (2017) report that ILC1 cells are not present in human tissues and that intraepithelial ILC1-like cells (ieILC1-like) are phenotypically similar to conventional NK cells. Gury-BenAri et al. reported that mouse ILC subsets comprise more heterogeneous populations than previously reported based on single cell RNA-seq analysis (Gury-BenAri et al., 2016). ILC3c is distinct from other ILC3s in that this population expresses a high level of IL-22. ILC3b population seems to correspond to NKp46+ ILC3 and ILC3e population contains lymphoid tissue inducer (LTi)-like cells and cells expressing MHCII, which was not expressed in human ILCs (Simoni et al., 2017) It is not known, however, whether distinct populations found in ILC1 and ILC2 subsets have different in vivo functions in the mouse.
Immunity  , 10-13DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions