P4HA1: A single-gene surrogate of hypoxia signatures in oral squamous cell carcinoma patients Matthias Kappler, Johanna Kotrba, Tom Kaune, Matthias Bache,

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P4HA1: A single-gene surrogate of hypoxia signatures in oral squamous cell carcinoma patients Matthias Kappler, Johanna Kotrba, Tom Kaune, Matthias Bache, Swetlana Rot, Daniel Bethmann, Henri Wichmann, Antje Güttler, Udo Bilkenroth, Susanne Horter, Lisa Gallwitz, Jacqueline Kessler, Thomas Greither, Helge Taubert, Alexander W. Eckert, Dirk Vordermark Clinical and Translational Radiation Oncology Volume 5, Pages 6-11 (August 2017) DOI: 10.1016/j.ctro.2017.05.002 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 Multivariate Cox’s hazard regression model: association of P4HA1 mRNA expression level and survival of OSCC patients. The model was adjusted to patients tumor stage, lymph status (N-stage) and grading of the tumor. The OSCC cohort was divided into four groups (quartiles) according to the intratumoral P4HA1 mRNA level (low, moderate, high, very high). The patients risk of death was calculated as RR=1.8 (P=0.12) for a moderate, RR=2.0 (P=0.075) for a high and RR=2.2 (P=0.039) for a very high intratumoral P4HA1 mRNA expression compared to the control group (low level). Clinical and Translational Radiation Oncology 2017 5, 6-11DOI: (10.1016/j.ctro.2017.05.002) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Multivariate Cox’s hazard regression model: association of P4HA1 mRNA expression level and locoregional recurrence of OSCC patients. The model was adjusted to patients tumor stage, lymph status (N-stage) and grading of the tumor. The OSCC cohort was divided into two groups according to the median intratumoral P4HA1 mRNA levels. The risk of recurrence was calculated as RR=2.6 (P=0.16) for a moderate, RR=5.8 (P=0.008) for a high and RR=4.8 (P=0.023) for a very high intratumoral P4HA1 mRNA expression compared to the control group (low level). Clinical and Translational Radiation Oncology 2017 5, 6-11DOI: (10.1016/j.ctro.2017.05.002) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 P4HA1 mRNA expression level of the OSCC cell lines CAL-33, XF354 and SAS. Cells were cultivated for 24h under culture conditions of 21% oxygen (normoxia) or 0.1% oxygen (hypoxia). The mRNA level in the cell lines CAL-33, XF354 and SAS were upregulated, when cells were cultivated under hypoxic conditions by the factor of 10.8, 9.8 and 4.8, respectively. Clinical and Translational Radiation Oncology 2017 5, 6-11DOI: (10.1016/j.ctro.2017.05.002) Copyright © 2017 The Authors Terms and Conditions