1. Volume 68, Issue 6, Pages 1089-1097 (December 2015)
Polymorphisms of Genes Involved in Glucose and Energy Metabolic Pathways and Prostate Cancer: Interplay with Metformin 
Teemu J. Murtola, Tiina Wahlfors, Antti Haring, Kimmo Taari, Ulf-Håkan Stenman, Teuvo L.J. Tammela, Johanna Schleutker, Anssi Auvinen 
European Urology 
Volume 68, Issue 6, Pages (December 2015)
DOI: /j.eururo
Copyright © 2015 European Association of Urology Terms and Conditions

2. Fig. 1
Prostate cancer risk among men stratified by a genetic risk score based on single-nucleotide polymorphisms of genes involved in glucose and energy metabolic pathways. Cohort of 3241 participants from the screening arm of the Finnish Prostate Cancer Screening Trial (FinPCST) between 1995 and The p value for trends were calculated by adding the genetic risk score as a continuous variable to the age-adjusted Cox regression model. (A) Overall risk of prostate cancer. (B) Risk of Gleason 7–10 prostate cancer. HR=hazard ratio; CI=confidence interval.
European Urology  , DOI: ( /j.eururo )
Copyright © 2015 European Association of Urology Terms and Conditions

3. Fig. 2
Decision curve analysis for prostate cancer survival after diagnosis using the genetic risk score and known prognostic factors among prostate cancer cases from the combined study cohorts. dg=diagnosis; PSA=prostate-specific antigen.
European Urology  , DOI: ( /j.eururo )
Copyright © 2015 European Association of Urology Terms and Conditions

4. Fig. 3
Effect of antidiabetic drug use on the association between prostate cancer risk and survival and the genetic risk score calculated based on single-nucleotide polymorphisms of genes involved in the glucose and energy metabolic pathways. Cohort of 3241 participants in the screening arm of the Finnish Prostate Cancer Screening Trial between 1995 and Men with a genetic risk score above the median compared to those with a risk score below the median. (A) Overall prostate cancer risk. Hazard ratio (HR) from Cox regression with model adjustment for age. (B) Risk of high-grade (Gleason 7–10) prostate cancer. HR from Cox regression with model adjustment for age. (C) Risk of prostate cancer death. HR from Cox regression with model adjustment for age, PSA at diagnosis, tumour Gleason grade, and M stage. CI=confidence interval; DM=diabetes mellitus.
European Urology  , DOI: ( /j.eururo )
Copyright © 2015 European Association of Urology Terms and Conditions