IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life

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Presentation transcript:

IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life Christina Weber-Chrysochoou, MD, Daniel Crisafulli, BSc, Catarina Almqvist, PhD, Qiang Li, BSc, Andrew S. Kemp, PhD, Warwick J. Britton, PhD, Guy B. Marks, PhD Journal of Allergy and Clinical Immunology Volume 120, Issue 2, Pages 286-292 (August 2007) DOI: 10.1016/j.jaci.2007.06.034 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Box and whiskers plots showing the distribution of IL-5, IL-10, and IFN-γ responses at 18 months, 3 years, and 5 years and IL-13 responses at 3 years and 5 years. The following numbers of observations representing extreme outliers are not shown: 2 for IL-5 at 5 years, 3 for IL-13 at 5 years, 2 for IL-10 at 18 months, 2 for IL-10 at 3 years; 1 for IFN-γ at 18 months, and 3 for IFN-γ at 3 years. Journal of Allergy and Clinical Immunology 2007 120, 286-292DOI: (10.1016/j.jaci.2007.06.034) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Prevalence of IL-5, IL-13, IL-10, and IFN-γ responses at 18 months, 3 years, and 5 years in relation to allergic sensitization (any SPT wheal ≥2 mm) at 5 years. Subjects are classified as nonresponders (<10 pg/mL), low responders (10-50 pg/mL), or high responders (>50 pg/mL) for IL-5, IL-13, and IL-10, and as nonresponders (<50 pg/mL) or responders (>50 pg/mL) for IFN-γ. P values are derived from logistic regression models testing HDM-specific cytokine responses at 18 months, 3 years, and 5 years in a single model for each cytokine and represent the significance of the cytokine at the specified time point, after adjustment for response of that cytokine at other time points. Error bars represent 95% CIs. nt, No valid cytokine result. Journal of Allergy and Clinical Immunology 2007 120, 286-292DOI: (10.1016/j.jaci.2007.06.034) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 The relation between HDM-specific IL-5 responses at 3 years and 5 years and the presence of allergic sensitization, asthma, and eczema at 5 years. Relative risks for low responders (10-50 pg/mL) and high responders (>50 pg/mL) compared with nonresponders (<10 pg/mL) are shown with 95% CIs. Relative risks are adjusted for other cytokines measured at the same age. Journal of Allergy and Clinical Immunology 2007 120, 286-292DOI: (10.1016/j.jaci.2007.06.034) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions