Fig. 2 Elastic fiber fragmentation and SMC disarray in descending aorta of Fbln4E57K/E57K mice. Elastic fiber fragmentation and SMC disarray in descending.

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Fig. 2 Elastic fiber fragmentation and SMC disarray in descending aorta of Fbln4E57K/E57K mice. Elastic fiber fragmentation and SMC disarray in descending aorta of Fbln4E57K/E57K mice. Transmission electron micrographs of descending aorta of 3-month-old Fbln4E57K/E57K and littermate mice (Fbln4+/+ and Fbln4+/E57K). (A and B) In addition to severe elastic fiber fragmentation, there is increased medial wall thickness and SMC disarray in the aorta of Fbln4E57K/E57K mice. At higher magnification, the moth-eaten or spongy appearance of the fragmented elastic fibers (B) and variable (arrows = larger) collagen fibril size (C) are appreciated in the aorta of Fbln4E57K/E57K mice. Asterisks indicate vessel lumen. Carmen M. Halabi et al. Sci Adv 2017;3:e1602532 Published by AAAS